FK506 in a biodegradable glycolide-co-clatide-co-caprolactone polymer for prolongation of corneal allograft survival

doi:10.1080/02713680500320752

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	FK506 in a biodegradable glycolide-co-clatide-co-caprolactone polymer for prolongation of corneal allograft survival
	Shi, WY ; Liu, T ; Xie, LX ; Wang, SG
刊名	CURRENT EYE RESEARCH
	2005-11-01
卷号	30 期号:11 页码:969-976
关键词	Corneal Allograft Fk506 Immune Suppression Pglc
ISSN号	0271-3683
DOI	10.1080/02713680500320752
英文摘要	Purpose: FK506 has been extensively used in preventing immune rejection for human organ transplantation. This study aimed to evaluate the effects of a biodegradable FK506 drug delivery system (DDS) implanted into anterior chamber for the prolongation of corneal allograft survival in high-risk keratoplasty. Methods: Biodegradable glycolide-co-clatide-co-caprolactone polymer (PGLC) was used as drug carrier to be incorporated with 0.5 mg of FK506 powder. The drug release from the FK506-PGLC DDS was evaluated in vitro and in vivo. The FK506-PGLCDDS was implanted into the anterior chamber of 12 high-risk keratoplasty rabbits. The graft survival time and clinical features of the FK506-PGLC DDS group were compared with the untreated, PGLC DDS, cyclosporin A-PGLC DDS, and 0.5% FK506 drops groups. The histopathological examination was performed to evaluate the safety of the FK506-PGLC DDS. Results: The mean graft survival time was longest (> 180 days) in the FK506-PGLC DDS group. In vivo, the FK506 concentration in aqueous humor peaked on day 28 (17.9 +/- 2.3 ng/ml) and kept a sustained release for at least 168 days. No adverse reactions were observed in the FK506-PGLC DDS group. Conclusions: Biodegradable FK506-PGLC DDS implanted into anterior chamber can effectively prevent immune rejection in high-risk keratoplasty model, presenting a promising approach for the prolongation of corneal allograft survival.
语种	英语
出版者	TAYLOR & FRANCIS INC
WOS记录号	WOS:000233940200006
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/56563]
专题	中国科学院化学研究所
通讯作者	Xie, LX
作者单位	1.Shandong Eye Inst, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Shi, WY,Liu, T,Xie, LX,et al. FK506 in a biodegradable glycolide-co-clatide-co-caprolactone polymer for prolongation of corneal allograft survival[J]. CURRENT EYE RESEARCH,2005,30(11):969-976.
APA	Shi, WY,Liu, T,Xie, LX,&Wang, SG.(2005).FK506 in a biodegradable glycolide-co-clatide-co-caprolactone polymer for prolongation of corneal allograft survival.CURRENT EYE RESEARCH,30(11),969-976.
MLA	Shi, WY,et al."FK506 in a biodegradable glycolide-co-clatide-co-caprolactone polymer for prolongation of corneal allograft survival".CURRENT EYE RESEARCH 30.11(2005):969-976.