Characterization of surface property of poly(lactide-co-glycolide) after oxygen plasma treatment

doi:10.1016/j.biomaterials.2003.11.051

CORC > 化学研究所 > 中国科学院化学研究所

	Characterization of surface property of poly(lactide-co-glycolide) after oxygen plasma treatment
	Wang, YQ ; Qu, X ; Lu, J ; Zhu, CF ; Wan, LJ ; Yang, JL ; Bei, JZ ; Wang, SG
刊名	BIOMATERIALS
	2004-08-01
卷号	25 期号:19 页码:4777-4783
关键词	Plasma Poly(Lactide-co-glycolide) (Plga) Cell Affinity Shear Stress Tissue Engineering
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2003.11.051
英文摘要	In this study, poly (lactide-co-glycolide) (PLGA) films were treated by oxygen plasma. The surface structure. topography and surface chemistry of treated PLGA films were characterized by contact angle measurement, scanning electron microscope observation. atomic force microscopy, and X-ray photoelectron spectrum analysis. The cell affinity of the oxygen plasma treated films was evaluated under dynamic conditions by Parallel Plate Flow Chamber (PPFC). The results showed that the hydrophilicity increased greatly after oxygen plasma treatment. High quantities of -C-O groups, Such as hydroxyl and peroxyl groups could be incorporated into the surface of PLGA (70/30) by controlling appropriate plasma treatment conditions. Moreover, the oxygen plasma treatment resulted in formation of peaks and valleys on the sample surfaces, and the roughness increased with treatment time. Cells stretched very well and the ability to endure the shear stress was improved greatly after the PLGA (70/30) was modified by appropriate plasma treatment. i.e. under 50 W for 2 or 10 min. However, when the treatment time was increased to 20 min, the percentage of adherent cells on the roughest surface decreased because the content of polar groups incorporated onto the surface decreased. The results showed that improved cell adhesion was attributed to the combination of surface chemistry and surface morphology of PLGA during plasma etching. (C) 2003 Elsevier Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000221211400029
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/55203]
专题	中国科学院化学研究所
通讯作者	Wang, SG
作者单位	1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Wang, YQ,Qu, X,Lu, J,et al. Characterization of surface property of poly(lactide-co-glycolide) after oxygen plasma treatment[J]. BIOMATERIALS,2004,25(19):4777-4783.
APA	Wang, YQ.,Qu, X.,Lu, J.,Zhu, CF.,Wan, LJ.,...&Wang, SG.(2004).Characterization of surface property of poly(lactide-co-glycolide) after oxygen plasma treatment.BIOMATERIALS,25(19),4777-4783.
MLA	Wang, YQ,et al."Characterization of surface property of poly(lactide-co-glycolide) after oxygen plasma treatment".BIOMATERIALS 25.19(2004):4777-4783.