Versatile Fluorescent Conjugated Polyelectrolyte-Capped Mesoporous Silica Nanoparticles for Controlled Drug Delivery and Imaging

doi:10.1002/cplu.201300135

CORC > 化学研究所 > 中国科学院化学研究所

	Versatile Fluorescent Conjugated Polyelectrolyte-Capped Mesoporous Silica Nanoparticles for Controlled Drug Delivery and Imaging
	Pu, Fang 1,2; Liu, Xia 1,2; Yang, Xinjian 1,2,3; Liu, Zhen 1,2,3; Ren, Jinsong 1,2; Wang, Shu 4; Qu, Xiaogang 1,2
刊名	CHEMPLUSCHEM
	2013-07-01
卷号	78 期号:7 页码:656-662
关键词	Drug Delivery Fluorescent Probes Mesoporous Materials Nanoparticles Toxicology
ISSN号	2192-6506
DOI	10.1002/cplu.201300135
英文摘要	Fluorescent conjugated polyelectrolytes (CPEs) with a large extinction coefficient, high quantum efficiency, good photostability, and efficient intramolecular/intermolecular exciton migration have recently received great research attention as a new generation of fluorescent probes. Herein, the unique properties of fluorescent conjugated polyelectrolyte and mesoporous silica nanoparticles (MSNs) are combined to prepare a pH-sensitive drug delivery and cellular imaging system using a simple and more general method. To the best of our knowledge, this is the first proof-of-concept investigation on the use of fluorescent conjugated polyelectrolyte as both the capping agent of MSNs and the cellular imaging probe in parallel. Moreover, the bifunctional nanomaterial exhibits low cytotoxicity and good biocompatibility demonstrated by a cytotoxicity assay against HepG2 cells and a hemolysis assay against human red-blood cells. It is a promising candidate for simultaneous diagnostics and therapeutics and can also provide a general strategy to develop novel multifunctional nanomedical systems.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000321430900013
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/54213]
专题	中国科学院化学研究所
通讯作者	Ren, Jinsong
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, Biol Chem Lab, Changchun 130022, Jilin, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 4.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Pu, Fang,Liu, Xia,Yang, Xinjian,et al. Versatile Fluorescent Conjugated Polyelectrolyte-Capped Mesoporous Silica Nanoparticles for Controlled Drug Delivery and Imaging[J]. CHEMPLUSCHEM,2013,78(7):656-662.
APA	Pu, Fang.,Liu, Xia.,Yang, Xinjian.,Liu, Zhen.,Ren, Jinsong.,...&Qu, Xiaogang.(2013).Versatile Fluorescent Conjugated Polyelectrolyte-Capped Mesoporous Silica Nanoparticles for Controlled Drug Delivery and Imaging.CHEMPLUSCHEM,78(7),656-662.
MLA	Pu, Fang,et al."Versatile Fluorescent Conjugated Polyelectrolyte-Capped Mesoporous Silica Nanoparticles for Controlled Drug Delivery and Imaging".CHEMPLUSCHEM 78.7(2013):656-662.