Shaped core/shell polymer nanoobjects with high antibacterial activities via block copolymer microphase separation

doi:10.1016/j.polymer.2013.05.005

CORC > 化学研究所 > 中国科学院化学研究所

	Shaped core/shell polymer nanoobjects with high antibacterial activities via block copolymer microphase separation
	Yao, Dongdong 1; Guo, Yujuan 2; Chen, Shiguo 2; Tang, Jiaoning 2; Chen, Yongming 1
刊名	POLYMER
	2013-06-01
卷号	54 期号:14 页码:3485-3491
关键词	Antibacterial Activities Block Copolymer Microphase Separation Shaped Polymer Nanoobjects
ISSN号	0032-3861
DOI	10.1016/j.polymer.2013.05.005
英文摘要	We report a procedure to fabricate antibacterial core/shell polymer nanoobjects with sheetlike, cylindrical, and spherical shapes. These shaped nanoobjects with chemically cross-linked polysiloxane cores and densely grafted polyammoniums shells were prepared by dispersing cross-linked microphase-separated materials of diblock copolymers, poly(2-(dimethylamino)ethyl methacrylate)-block-poly (3-(triethoxysilyl)propyl methacrylate) (PDMAEMA-b-PTEPM). Shapes of the nanoobjects were controlled by block copolymer composition, namely the microphase-separated structures. Then the tethered PDMAEMA shells were further quaternized with n-octyl bromide. The diblock copolymers, microphase-separated materials and shaped nanoobjects before and after quaternization were studied by H-1 NMR, size exclusion chromatography (SEC), small-angle X-ray scattering (SAXS) and transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FT-IR). The antibacterial activities of these quaternized nanoobjects have been preliminarily assessed against bacteria Escherichia coli (E. coli) (8099). The minimum bactericidal concentration (MBC) of the sheets, cylinders and spheres were 1.00, 0.66, 0.66 mg/mL. The antibacterial activities of the quaternized nanoobjects were nearly ten times higher than that of quaternized PDMAEMA homopolymer. (C) 2013 Elsevier Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000320679600008
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/54119]
专题	中国科学院化学研究所
通讯作者	Chen, Shiguo
作者单位	1.Chinese Acad Sci, Lab Polymer Phys & Chem, Inst Chem, Beijing 100190, Peoples R China 2.Shenzhen Univ, Shenzhen Key Lab Special Funct Mat, Coll Mat Sci & Engn, Shenzhen 518060, Peoples R China
推荐引用方式 GB/T 7714	Yao, Dongdong,Guo, Yujuan,Chen, Shiguo,et al. Shaped core/shell polymer nanoobjects with high antibacterial activities via block copolymer microphase separation[J]. POLYMER,2013,54(14):3485-3491.
APA	Yao, Dongdong,Guo, Yujuan,Chen, Shiguo,Tang, Jiaoning,&Chen, Yongming.(2013).Shaped core/shell polymer nanoobjects with high antibacterial activities via block copolymer microphase separation.POLYMER,54(14),3485-3491.
MLA	Yao, Dongdong,et al."Shaped core/shell polymer nanoobjects with high antibacterial activities via block copolymer microphase separation".POLYMER 54.14(2013):3485-3491.