Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells

doi:10.1002/cbf.2905

CORC > 化学研究所 > 中国科学院化学研究所

	Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells
	Yang, Yong 1; Wolfram, Joy 1; Boom, Kathryn 1; Fang, Xiaohong 2; Shen, Haifa 1,3; Ferrari, Mauro 1,4
刊名	CELL BIOCHEMISTRY AND FUNCTION
	2013-07-01
卷号	31 期号:5 页码:374-379
关键词	Hesperetin Glucose Uptake Glut1 Glut4 Breast Cancer Cells
ISSN号	0263-6484
DOI	10.1002/cbf.2905
英文摘要	The flavanone hesperetin is known to decrease basal glucose uptake, although the inhibitory mechanism is largely unknown. Here, we used MDA-MB-231 breast cancer cells to investigate the molecular pathways affected by hesperetin. The results indicate that the suppression of glucose uptake is caused by the down-regulation of glucose transporter 1 (GLUT1). Hesperetin was also found to inhibit insulin-induced glucose uptake through impaired cell membrane translocation of glucose transporter 4 (GLUT4). In addition, the phosphorylation of the insulin receptor-beta subunit (IR-beta) and Akt was suppressed. Hesperetin also decreased cellular proliferation, which is likely due to the inhibition of glucose uptake. Cancer cells are highly dependent on glucose and hesperetin may, therefore, have potential application as an anticancer agent. Copyright (c) 2012 John Wiley & Sons, Ltd.
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000322154400003
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/54061]
专题	中国科学院化学研究所
通讯作者	Ferrari, Mauro
作者单位	1.Methodist Hosp, Res Inst, Dept Nanomed, Houston, TX 77030 USA 2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China 3.Weill Cornell Med Coll, Dept Cell & Dev Biol, New York, NY USA 4.Weill Cornell Med Coll, Dept Med, New York, NY USA
推荐引用方式 GB/T 7714	Yang, Yong,Wolfram, Joy,Boom, Kathryn,et al. Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells[J]. CELL BIOCHEMISTRY AND FUNCTION,2013,31(5):374-379.
APA	Yang, Yong,Wolfram, Joy,Boom, Kathryn,Fang, Xiaohong,Shen, Haifa,&Ferrari, Mauro.(2013).Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells.CELL BIOCHEMISTRY AND FUNCTION,31(5),374-379.
MLA	Yang, Yong,et al."Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells".CELL BIOCHEMISTRY AND FUNCTION 31.5(2013):374-379.