Cinchona Alkaloid Squaramide Catalyzed Enantioselective Hydrazination/Cyclization Cascade Reaction of alpha-Isocyanoacetates and Azodicarboxylates: Synthesis of Optically Active 1,2,4-Triazolines

doi:10.1021/jo401585v

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	Cinchona Alkaloid Squaramide Catalyzed Enantioselective Hydrazination/Cyclization Cascade Reaction of alpha-Isocyanoacetates and Azodicarboxylates: Synthesis of Optically Active 1,2,4-Triazolines
	Zhao, Mei-Xin 1,2,3; Bi, Hong-Lei 1,2; Zhou, Hao 1,2; Yang, Hui 1,2; Shi, Min 1,2,4
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2013-09-20
卷号	78 期号:18 页码:9377-9382
ISSN号	0022-3263
DOI	10.1021/jo401585v
英文摘要	An efficient enantioselective hydrazination/cyclization cascade reaction of alpha-substituted isocyanoacetates to azodicarboxylates catalyzed by Cinchona alkaloid derived squaramide catalysts has been investigated, affording the optically active 1,2,4-triazolines in excellent yields (up to 99%) and good to excellent enantioselectivities (up to 97% ee) under mild conditions.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000330159500047
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/54007]
专题	中国科学院化学研究所
通讯作者	Zhao, Mei-Xin
作者单位	1.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China 2.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Mei-Xin,Bi, Hong-Lei,Zhou, Hao,et al. Cinchona Alkaloid Squaramide Catalyzed Enantioselective Hydrazination/Cyclization Cascade Reaction of alpha-Isocyanoacetates and Azodicarboxylates: Synthesis of Optically Active 1,2,4-Triazolines[J]. JOURNAL OF ORGANIC CHEMISTRY,2013,78(18):9377-9382.
APA	Zhao, Mei-Xin,Bi, Hong-Lei,Zhou, Hao,Yang, Hui,&Shi, Min.(2013).Cinchona Alkaloid Squaramide Catalyzed Enantioselective Hydrazination/Cyclization Cascade Reaction of alpha-Isocyanoacetates and Azodicarboxylates: Synthesis of Optically Active 1,2,4-Triazolines.JOURNAL OF ORGANIC CHEMISTRY,78(18),9377-9382.
MLA	Zhao, Mei-Xin,et al."Cinchona Alkaloid Squaramide Catalyzed Enantioselective Hydrazination/Cyclization Cascade Reaction of alpha-Isocyanoacetates and Azodicarboxylates: Synthesis of Optically Active 1,2,4-Triazolines".JOURNAL OF ORGANIC CHEMISTRY 78.18(2013):9377-9382.