Hybrid polymer micelles capable of cRGD targeting and pH-triggered surface charge conversion for tumor selective accumulation and promoted uptake

doi:10.1039/c4cc04056b

CORC > 化学研究所 > 中国科学院化学研究所

	Hybrid polymer micelles capable of cRGD targeting and pH-triggered surface charge conversion for tumor selective accumulation and promoted uptake
	Hu, Xiuli 1; Guan, Xingang 1,2; Li, Jing 1; Pei, Qing 1,3; Liu, Ming 1,3; Xie, Zhigang 1; Jing, Xiabin 1
刊名	CHEMICAL COMMUNICATIONS
	2014-08-21
卷号	50 期号:65 页码:9188-9191
ISSN号	1359-7345
DOI	10.1039/c4cc04056b
英文摘要	This study presents both tumor-targeting ligands (cRGD) and pH-activated surface charge-conversional moiety (imidazole) decorated micelles for Dox delivery. cRGD is expected to induce preferential tumor accumulation, while imidazole switches on positive charge in a tumor acid environment, which leads to enhanced micelle uptake by tumor cells.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000339930400041
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/52339]
专题	中国科学院化学研究所
通讯作者	Xie, Zhigang
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Beihua Univ, Life Sci Res Ctr, Jilin 132013, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Hu, Xiuli,Guan, Xingang,Li, Jing,et al. Hybrid polymer micelles capable of cRGD targeting and pH-triggered surface charge conversion for tumor selective accumulation and promoted uptake[J]. CHEMICAL COMMUNICATIONS,2014,50(65):9188-9191.
APA	Hu, Xiuli.,Guan, Xingang.,Li, Jing.,Pei, Qing.,Liu, Ming.,...&Jing, Xiabin.(2014).Hybrid polymer micelles capable of cRGD targeting and pH-triggered surface charge conversion for tumor selective accumulation and promoted uptake.CHEMICAL COMMUNICATIONS,50(65),9188-9191.
MLA	Hu, Xiuli,et al."Hybrid polymer micelles capable of cRGD targeting and pH-triggered surface charge conversion for tumor selective accumulation and promoted uptake".CHEMICAL COMMUNICATIONS 50.65(2014):9188-9191.