Organocatalytic [4+2] cyclocondensation of alpha,beta-unsaturated acyl chlorides with imines: highly enantioselective synthesis of dihydropyridinone and piperidine derivatives

doi:10.1039/c4ob00114a

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	Organocatalytic [4+2] cyclocondensation of alpha,beta-unsaturated acyl chlorides with imines: highly enantioselective synthesis of dihydropyridinone and piperidine derivatives
	Jia, Wen-Qiang; Chen, Xiang-Yu; Sun, Li-Hui; Ye, Song
刊名	ORGANIC & BIOMOLECULAR CHEMISTRY
	2014
卷号	12 期号:14 页码:2167-2171
ISSN号	1477-0520
DOI	10.1039/c4ob00114a
英文摘要	The cinchona alkaloid-catalyzed [4 + 2] cyclocondensation of alpha,beta-unsaturated acyl chlorides with imines is developed to give the corresponding substituted dihydropyridinones in good yields with high to excellent enantioselectivities. Reduction of the dihydropyridinones gave highly optically active substituted tetrahydropyridinone and piperidine derivatives.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000333037500002
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/52261]
专题	中国科学院化学研究所
通讯作者	Ye, Song
作者单位	Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Jia, Wen-Qiang,Chen, Xiang-Yu,Sun, Li-Hui,et al. Organocatalytic [4+2] cyclocondensation of alpha,beta-unsaturated acyl chlorides with imines: highly enantioselective synthesis of dihydropyridinone and piperidine derivatives[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2014,12(14):2167-2171.
APA	Jia, Wen-Qiang,Chen, Xiang-Yu,Sun, Li-Hui,&Ye, Song.(2014).Organocatalytic [4+2] cyclocondensation of alpha,beta-unsaturated acyl chlorides with imines: highly enantioselective synthesis of dihydropyridinone and piperidine derivatives.ORGANIC & BIOMOLECULAR CHEMISTRY,12(14),2167-2171.
MLA	Jia, Wen-Qiang,et al."Organocatalytic [4+2] cyclocondensation of alpha,beta-unsaturated acyl chlorides with imines: highly enantioselective synthesis of dihydropyridinone and piperidine derivatives".ORGANIC & BIOMOLECULAR CHEMISTRY 12.14(2014):2167-2171.