Unique features of the m(6)A methylome in Arabidopsis thaliana

doi:10.1038/ncomms6630

CORC > 化学研究所 > 中国科学院化学研究所

	Unique features of the m(6)A methylome in Arabidopsis thaliana
	Luo, Guan-Zheng 1,2,3; MacQueen, Alice 4; Zheng, Guanqun 1,2,3; Duan, Hongchao 5; Dore, Louis C.1,2,3; Lu, Zhike 1,2,3; Liu, Jun ; Chen, Kai 1,2,3; Jia, Guifang 5; Bergelson, Joy 4
刊名	NATURE COMMUNICATIONS
	2014-11-01
卷号	5
ISSN号	2041-1723
DOI	10.1038/ncomms6630
英文摘要	Recent discoveries of reversible N-6-methyladenosine (m(6)A) methylation on messenger RNA (mRNA) and mapping of m(6)A methylomes in mammals and yeast have revealed potential regulatory functions of this RNA modification. In plants, defects in m(6)A methyltransferase cause an embryo-lethal phenotype, suggesting a critical role of m(6)A in plant development. Here, we profile m(6)A transcriptome-wide in two accessions of Arabidopsis thaliana and reveal that m(6)A is a highly conserved modification of mRNA in plants. Distinct from mammals, m(6)A in A. thaliana is enriched not only around the stop codon and within 30-untranslated regions, but also around the start codon. Gene ontology analysis indicates that the unique distribution pattern of m(6)A in A. thaliana is associated with plant-specific pathways involving the chloroplast. We also discover a positive correlation between m(6)A deposition and mRNA abundance, suggesting a regulatory role of m(6)A in plant gene expression.
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000346145600001
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/52005]
专题	中国科学院化学研究所
通讯作者	Luo, Guan-Zheng
作者单位	1.Univ Chicago, Dept Chem, Chicago, IL 60637 USA 2.Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USA 3.Univ Chicago, Howard Hughes Med Inst, Chicago, IL 60637 USA 4.Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA 5.Peking Univ, Coll Chem & Mol Engn, Synthet & Funct Biomol Ctr,Minist Educ, Beijing Natl Lab Mol Sci,Key Lab Bioorgan Chem &, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Luo, Guan-Zheng,MacQueen, Alice,Zheng, Guanqun,et al. Unique features of the m(6)A methylome in Arabidopsis thaliana[J]. NATURE COMMUNICATIONS,2014,5.
APA	Luo, Guan-Zheng.,MacQueen, Alice.,Zheng, Guanqun.,Duan, Hongchao.,Dore, Louis C..,...&He, Chuan.(2014).Unique features of the m(6)A methylome in Arabidopsis thaliana.NATURE COMMUNICATIONS,5.
MLA	Luo, Guan-Zheng,et al."Unique features of the m(6)A methylome in Arabidopsis thaliana".NATURE COMMUNICATIONS 5(2014).