Electrospun Tubular Scaffold with Circumferentially Aligned Nanofibers for Regulating Smooth Muscle Cell Growth

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	Electrospun Tubular Scaffold with Circumferentially Aligned Nanofibers for Regulating Smooth Muscle Cell Growth
	Wang, Yanming 1; Shi, Haigang 1; Qiao, Jing 1; Tian, Ye 1; Wu, Man 1; Zhang, Wei 1; Lin, Yuan 2; Niu, Zhongwei 1; Huang, Yong 1
刊名	ACS APPLIED MATERIALS & INTERFACES
	2014-02-26
卷号	6 期号:4 页码:2958-2962
关键词	Electrospinning Alignment Tubular Scaffold Cell Culture Smooth Muscle Cells Phenotype
ISSN号	1944-8244
英文摘要	Simulation for the smooth muscle layer of blood vessel plays a key role in tubular tissue engineering. However, fabrication of biocompatible tube with defined inner nano/micro-structure remains a challenge. Here, we show that a biocompatible polymer tube from poly(L-lactide) (PLLA) and polydimethylsiloxane (PDMS) can be prepared by using electrospinning technique, with assistance of rotating collector and parallel auxiliary electrode. The tube has circumferentially aligned PLLA fibers in the inner surface for cell growth regulation and has a PDMS coating for better compressive property. MTT assay showed the composite PLLA/PDMS tube was suitable for various cells growth. In vitro smooth muscle cells (SMCs) cultured in the tube showed that the aligned PLLA fibers could induce SMCs' orientation, and different expression of alpha-SMA and OPN genes were observed on the aligned and random PLLA fibers, respectively. The successful fabrication of composite PLLA/PDMS tubular scaffold for regulating smooth muscle cells outgrowth has important implications for tissue-engineered blood vessels.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000332144600099
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/51789]
专题	中国科学院化学研究所
通讯作者	Lin, Yuan
作者单位	1.Chinese Acad Sci, Tech Inst Phys & Chem, Natl Res Ctr Engn Plast, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yanming,Shi, Haigang,Qiao, Jing,et al. Electrospun Tubular Scaffold with Circumferentially Aligned Nanofibers for Regulating Smooth Muscle Cell Growth[J]. ACS APPLIED MATERIALS & INTERFACES,2014,6(4):2958-2962.
APA	Wang, Yanming.,Shi, Haigang.,Qiao, Jing.,Tian, Ye.,Wu, Man.,...&Huang, Yong.(2014).Electrospun Tubular Scaffold with Circumferentially Aligned Nanofibers for Regulating Smooth Muscle Cell Growth.ACS APPLIED MATERIALS & INTERFACES,6(4),2958-2962.
MLA	Wang, Yanming,et al."Electrospun Tubular Scaffold with Circumferentially Aligned Nanofibers for Regulating Smooth Muscle Cell Growth".ACS APPLIED MATERIALS & INTERFACES 6.4(2014):2958-2962.