Cinchona Alkaloid Squaramide/AgOAc Cooperatively Catalyzed Diastereo- and Enantioselective Mannich/Cyclization Cascade Reaction of Isocyanoacetates and Cyclic Trifluoromethyl Ketimines | |
Zhao, Mei-Xin1,2,3; Bi, Hong-Lei1,2; Jiang, Rong-Hui1,2; Xu, Xu-Wei1,2; Shi, Min1,2,4 | |
刊名 | ORGANIC LETTERS |
2014-09-05 | |
卷号 | 16期号:17页码:4566-4569 |
ISSN号 | 1523-7060 |
DOI | 10.1021/ol502123z |
英文摘要 | An efficient diastereo- and enantioselective Mannich-type/cyclization cascade reaction of alpha-substituted isocyanoacetates and cyclic trifluoromethyl ketimines cooperatively catalyzed by cinchona alkaloid-derived multi-hydrogen-bonding donor squaramide and AgOAc has been investigated, affording the optically active trifluoromethyl-substituted tetrahydroimidazo[1,5-c]-quinazoline derivatives in excellent yields (up to 99%) and good to excellent stereoselectivities (up to >15:1 dr, up to 9896 cc) under mild conditions. |
语种 | 英语 |
出版者 | AMER CHEMICAL SOC |
WOS记录号 | WOS:000341344600056 |
内容类型 | 期刊论文 |
源URL | [http://ir.iccas.ac.cn/handle/121111/51315] |
专题 | 中国科学院化学研究所 |
通讯作者 | Zhao, Mei-Xin |
作者单位 | 1.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China 2.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China |
推荐引用方式 GB/T 7714 | Zhao, Mei-Xin,Bi, Hong-Lei,Jiang, Rong-Hui,et al. Cinchona Alkaloid Squaramide/AgOAc Cooperatively Catalyzed Diastereo- and Enantioselective Mannich/Cyclization Cascade Reaction of Isocyanoacetates and Cyclic Trifluoromethyl Ketimines[J]. ORGANIC LETTERS,2014,16(17):4566-4569. |
APA | Zhao, Mei-Xin,Bi, Hong-Lei,Jiang, Rong-Hui,Xu, Xu-Wei,&Shi, Min.(2014).Cinchona Alkaloid Squaramide/AgOAc Cooperatively Catalyzed Diastereo- and Enantioselective Mannich/Cyclization Cascade Reaction of Isocyanoacetates and Cyclic Trifluoromethyl Ketimines.ORGANIC LETTERS,16(17),4566-4569. |
MLA | Zhao, Mei-Xin,et al."Cinchona Alkaloid Squaramide/AgOAc Cooperatively Catalyzed Diastereo- and Enantioselective Mannich/Cyclization Cascade Reaction of Isocyanoacetates and Cyclic Trifluoromethyl Ketimines".ORGANIC LETTERS 16.17(2014):4566-4569. |
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