Rhodium-Catalyzed Decarbonylative Direct C2-Arylation of Indoles with Aryl Carboxylic Acids

doi:10.1002/cctc.201402534

CORC > 化学研究所 > 中国科学院化学研究所

	Rhodium-Catalyzed Decarbonylative Direct C2-Arylation of Indoles with Aryl Carboxylic Acids
	Zhang, Lingjuan 1; Xue, Xiao 1; Xu, Conghui 1; Pan, Yixiao 1; Zhang, Guang 1; Xu, Lijin 1; Li, Huanrong 1; Shi, Zhangjie 2,3,4
刊名	CHEMCATCHEM
	2014-11-01
卷号	6 期号:11 页码:3069-3074
关键词	Anhydrides Carboxylic Acids Oxidation Rhodium Synthesis Design
ISSN号	1867-3880
DOI	10.1002/cctc.201402534
英文摘要	A Rh-1-catalyzed direct C2-arylation of indoles with diversely substituted aryl carboxylic acids has been developed using 2-pyrimidyl group as an easily installable and readily removable N-directing group. The reaction proceeded smoothly without the need for any external oxidants under relatively mild conditions to produce the C2-arylated indoles in high yields with excellent regioselectivity. A range of functional groups in both coupling partners were tolerated regardless of their electronic properties and positions. With the assistance of the 2-pyrimidyl group, these C2-functionalized products could further undergo C7-arylation to give the C7-aryl indole products. Mechanistic evidence supports that the reaction involves a decarbonylation step, and the carboxylic acids could be activated in situ by treatment with (tBuCO)(2)O to generate the active anhydrides.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000344330800006
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/51283]
专题	中国科学院化学研究所
通讯作者	Xu, Lijin
作者单位	1.Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China 2.Peking Univ, BNLMS, Beijing 100871, Peoples R China 3.Peking Univ, Key Lab Bioorgan Chem & Mol Engn Educ, Coll Chem, Beijing 100871, Peoples R China 4.Peking Univ, Green Chem Ctr, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Lingjuan,Xue, Xiao,Xu, Conghui,et al. Rhodium-Catalyzed Decarbonylative Direct C2-Arylation of Indoles with Aryl Carboxylic Acids[J]. CHEMCATCHEM,2014,6(11):3069-3074.
APA	Zhang, Lingjuan.,Xue, Xiao.,Xu, Conghui.,Pan, Yixiao.,Zhang, Guang.,...&Shi, Zhangjie.(2014).Rhodium-Catalyzed Decarbonylative Direct C2-Arylation of Indoles with Aryl Carboxylic Acids.CHEMCATCHEM,6(11),3069-3074.
MLA	Zhang, Lingjuan,et al."Rhodium-Catalyzed Decarbonylative Direct C2-Arylation of Indoles with Aryl Carboxylic Acids".CHEMCATCHEM 6.11(2014):3069-3074.