Immobilizing PEO-PPO-PEO triblock copolymers on hydrophobic surfaces and its effect on protein and platelet: A combined study using QCM-D and DPI

doi:10.1016/j.colsurfb.2014.10.038

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	Immobilizing PEO-PPO-PEO triblock copolymers on hydrophobic surfaces and its effect on protein and platelet: A combined study using QCM-D and DPI
	Jin, Jing 1; Huang, Fujian 2; Hu, Yu 1; Jiang, Wei 1; Ji, Xiangling 1; Liang, Haojun 2; Yin, Jinghua 1
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2014-11-01
卷号	123 页码:892-899
关键词	Dual Polarization Interferometry Quartz Crystal Microbalance With Dissipation Pluronic Protein Adsorption Platelet Adhesion
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2014.10.038
英文摘要	Dual polarization interferometry was used to monitor the immobilization dynamics of four Pluronics on hydrophobic surfaces and to elucidate the effect of Pluronic conformation on protein adsorption. The proportion of hydrophobic chain segments and not the length of the hydrophobic chain can influence the chain densities of the Pluronics. The immobilized densities of the Pluronics resulted from competition between the hydration of polyethylene oxide (PEO) in the aqueous solution and the hydrophobic interaction of polypropylene oxide on the substrate. P-123 obtained the largest graft mass (2.89 +/- 0.25 ng/mm(2)) because of the dominant effect of hydrophobic interactions. Hydrophobic segments of P-123 were anchored slowly and step-wise on the C18 substrate. P-123 exhibited the largest hydrophobic chain segment proportion (propylene oxide/ethylene oxide =3.63) and formed a brush chain conformation, indicating excellent protein and platelet resistance. The result of quartz crystal microbalance with dissipation further confirmed that the PEO conformation in P-123 on the substrate exhibited a relatively extended brush chain, and that L-35 showed relatively loose and pancake-like structures. The PEO in P-123 regulated the conformation to maintain the native conformation and resist the adsorption of bovine serum albumin (BSA). Thus, the hemocompatibilities of the immobilized Pluronics were influenced by the proportion of hydrophobic chain segments and their PEO conformations. Crown Copyright (C) 2014 Published by Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000347580500112
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/51133]
专题	中国科学院化学研究所
通讯作者	Jiang, Wei
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Univ Sci & Technol China, Dept Polymer Sci & Engn, Hefei 230026, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Jin, Jing,Huang, Fujian,Hu, Yu,et al. Immobilizing PEO-PPO-PEO triblock copolymers on hydrophobic surfaces and its effect on protein and platelet: A combined study using QCM-D and DPI[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2014,123:892-899.
APA	Jin, Jing.,Huang, Fujian.,Hu, Yu.,Jiang, Wei.,Ji, Xiangling.,...&Yin, Jinghua.(2014).Immobilizing PEO-PPO-PEO triblock copolymers on hydrophobic surfaces and its effect on protein and platelet: A combined study using QCM-D and DPI.COLLOIDS AND SURFACES B-BIOINTERFACES,123,892-899.
MLA	Jin, Jing,et al."Immobilizing PEO-PPO-PEO triblock copolymers on hydrophobic surfaces and its effect on protein and platelet: A combined study using QCM-D and DPI".COLLOIDS AND SURFACES B-BIOINTERFACES 123(2014):892-899.