Hydrophilic Block Azidation of PCL-b-PEO Block Copolymers from Epichlorohydrin

doi:10.1002/mabi.201300488

CORC > 化学研究所 > 中国科学院化学研究所

	Hydrophilic Block Azidation of PCL-b-PEO Block Copolymers from Epichlorohydrin
	Liu, Junjie 1,3; Gan, Zhihua 1,2
刊名	MACROMOLECULAR BIOSCIENCE
	2014-05-01
卷号	14 期号:5 页码:699-708
关键词	Block Copolymers Crosslinking Drug Delivery Systems Polymer Functionalization Polymers Self-assembly
ISSN号	1616-5187
DOI	10.1002/mabi.201300488
英文摘要	Amphiphilic diblock copolymers poly(epsilon-caprolactone)-b-poly(ethylene oxide) (PCL-b-PEO) with well-controlled pendant azido groups along the hydrophilic PEO block, that is, poly-(epsilon-caprolactone)-b-poly(ethylene oxide-co-glycidyl azide) (PCL-b-P(EO-co-GA)), are synthesized from poly(epsilon-caprolactone)-b-poly(ethylene oxide-co-epichlorohydrin) (PCL-b-P(EO-co-ECH)). The further conversion of those azido groups along the hydrophilic block of copolymers into amino or carboxyl groups via click chemistry is studied. The micelles self-assembled from PCL-b-P(EO-co-GA) with azido groups on the shell are crosslinked by the dialkynyl-PEO. The micelles with crosslinked shell show better stability, higher drug loading capacities, subsequent faster drug release rate, and higher cytotoxicity to cancer cells. The introduction of azido groups into PCL-b-PEO amphiphilic diblock copolymers from epichlorohydrin in PEO hydrophilic block in this work provides a new method for biofunctionalization of micelles via mild click chemistry.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000336244100010
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/50707]
专题	中国科学院化学研究所
通讯作者	Gan, Zhihua
作者单位	1.Chinese Acad Sci, CAS Key Lab Engn Plast, Inst Chem, Beijing 100190, Peoples R China 2.Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing Lab Biomed Mat, Coll Life Sci & Technol, Beijing 100029, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Liu, Junjie,Gan, Zhihua. Hydrophilic Block Azidation of PCL-b-PEO Block Copolymers from Epichlorohydrin[J]. MACROMOLECULAR BIOSCIENCE,2014,14(5):699-708.
APA	Liu, Junjie,&Gan, Zhihua.(2014).Hydrophilic Block Azidation of PCL-b-PEO Block Copolymers from Epichlorohydrin.MACROMOLECULAR BIOSCIENCE,14(5),699-708.
MLA	Liu, Junjie,et al."Hydrophilic Block Azidation of PCL-b-PEO Block Copolymers from Epichlorohydrin".MACROMOLECULAR BIOSCIENCE 14.5(2014):699-708.