Vertically Aligned Carbon Nanotube-Sheathed Carbon Fibers as Pristine Microelectrodes for Selective Monitoring of Ascorbate in Vivo

doi:10.1021/ac404232h

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	Vertically Aligned Carbon Nanotube-Sheathed Carbon Fibers as Pristine Microelectrodes for Selective Monitoring of Ascorbate in Vivo
	Xiang, Ling 1; Yu, Ping 1; Hao, Jie 1; Zhang, Meining 2; Zhu, Lin 3; Dai, Liming 3; Mao, Lanqun 1
刊名	ANALYTICAL CHEMISTRY
	2014-04-15
卷号	86 期号:8 页码:3909-3914
ISSN号	0003-2700
DOI	10.1021/ac404232h
英文摘要	Using as-synthesized vertically aligned carbon nanotube-sheathed carbon fibers (VACNT-CFs) as microelectrodes without any postsynthesis functionalization, we have developed in this study a new method for in vivo monitoring of ascorbate with high selectivity and reproducibility. The VACNT-CFs are formed via pyrolysis of iron phthalocyanine (FePc) on the carbon fiber support. After electrochemical pretreatment in 1.0 M NaOH solution, the pristine VACNT-CF microelectrodes exhibit typical microelectrode behavior with fast electron transfer kinetics for electrochemical oxidation of ascorbate and are useful for selective ascorbate monitoring even with other electroactive species (e.g., dopamine, uric acid, and 5-hydroxytryptamine) coexisting in rat brain. Pristine VACNT-CFs are further demonstrated to be a reliable and stable microelectrode for in vivo recording of the dynamic increase of ascorbate evoked by intracerebral infusion of glutamate. Use of a pristine VACNT-CF microelectrode can effectively avoid any manual electrode modification and is free from person-to-person and/or electrode-to-electrode deviations intrinsically associated with conventional CF electrode fabrication, which often involves electrode surface modification with randomly distributed CNTs or other pretreatments, and hence allows easy fabrication of highly selective, reproducible, and stable microelectrodes even by nonelectrochemists. Thus, this study offers a new and reliable platform for in vivo monitoring of neurochemicals (e.g., ascorbate) to largely facilitate future studies on the neurochemical processes involved in various physiological events.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000334658000035
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/50229]
专题	中国科学院化学研究所
通讯作者	Zhang, Meining
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China 3.Case Western Reserve Univ, Dept Macromol Sci & Engn, Cleveland, OH 44106 USA
推荐引用方式 GB/T 7714	Xiang, Ling,Yu, Ping,Hao, Jie,et al. Vertically Aligned Carbon Nanotube-Sheathed Carbon Fibers as Pristine Microelectrodes for Selective Monitoring of Ascorbate in Vivo[J]. ANALYTICAL CHEMISTRY,2014,86(8):3909-3914.
APA	Xiang, Ling.,Yu, Ping.,Hao, Jie.,Zhang, Meining.,Zhu, Lin.,...&Mao, Lanqun.(2014).Vertically Aligned Carbon Nanotube-Sheathed Carbon Fibers as Pristine Microelectrodes for Selective Monitoring of Ascorbate in Vivo.ANALYTICAL CHEMISTRY,86(8),3909-3914.
MLA	Xiang, Ling,et al."Vertically Aligned Carbon Nanotube-Sheathed Carbon Fibers as Pristine Microelectrodes for Selective Monitoring of Ascorbate in Vivo".ANALYTICAL CHEMISTRY 86.8(2014):3909-3914.