Enzymatic Degradation of Biocompatible Block Polyelectrolyte Micelles in Aqueous Solutions

doi:10.3969/j.issn.0251-0790.2012.09.039

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	Enzymatic Degradation of Biocompatible Block Polyelectrolyte Micelles in Aqueous Solutions
	Mao Jun; Bo Shu-Qin; Ji Xiang-Ling
刊名	CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
	2012-09-10
卷号	33 期号:9 页码:2099-2105
关键词	Block Polyelectrolyte Micelle Enzymatic Degradation Biocompatibility
ISSN号	0251-0790
DOI	10.3969/j.issn.0251-0790.2012.09.039
英文摘要	Enzymatic degradation behavior of biocompatible block polyelectrolyte poly (L-lactide)-b-poly[2(dimethylamino)ethyl methacrylate] (PLLA-b-PDMAEMA) micelles in aqueous solutions at two different temperatures(25. 0 degrees C, 36. 8 degrees C) and two different pH values(pH = 4. 9, 7. 4) was investigated by laser light scattering(LLS) and atomic force microscopy(AFM). It is found that there is an enzyme inactivation time during the degradation process. Before this time, the degradation mechanism of PLLA-b-PDMAEMA micelles follows a one-by-one process. After this time, the degraded micelles with cracks or tunnels in their cores aggregate into large micelles to minimize their surface area exposed to the solvent, therefore minimize the free energy of the micelles. After increasing temperature, the activity of the enzyme increases, and the degradation rate of micelles is much faster. At pH = 4. 9, the coronas of the micelles are stretched due to the electrostatic repulsion, because of which the degradation rate of micelles is faster at pH = 4. 9 than that at pH = 7. 4.
语种	英语
出版者	HIGHER EDUCATION PRESS
WOS记录号	WOS:000309631300039
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/49895]
专题	中国科学院化学研究所
通讯作者	Ji Xiang-Ling
作者单位	Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
推荐引用方式 GB/T 7714	Mao Jun,Bo Shu-Qin,Ji Xiang-Ling. Enzymatic Degradation of Biocompatible Block Polyelectrolyte Micelles in Aqueous Solutions[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2012,33(9):2099-2105.
APA	Mao Jun,Bo Shu-Qin,&Ji Xiang-Ling.(2012).Enzymatic Degradation of Biocompatible Block Polyelectrolyte Micelles in Aqueous Solutions.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,33(9),2099-2105.
MLA	Mao Jun,et al."Enzymatic Degradation of Biocompatible Block Polyelectrolyte Micelles in Aqueous Solutions".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 33.9(2012):2099-2105.