Efficient synthesis and self-assembly of hetero-grafted amphiphilic polypepide bottlebrushes

doi:10.1351/PAC-CON-12-02-07

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	Efficient synthesis and self-assembly of hetero-grafted amphiphilic polypepide bottlebrushes
	Luo, Chunhui; Chen, Chongyi; Li, Zhibo
刊名	PURE AND APPLIED CHEMISTRY
	2012
卷号	84 期号:12 页码:2569-2578
关键词	Amino Acids Bottlebrushes Click Chemistry Macromolecular Chemistry Polypeptides Polymer Chemistry Ring-opening Reactions Self-assembly
ISSN号	0033-4545
DOI	10.1351/PAC-CON-12-02-07
英文摘要	A new type of hetero-grafted molecular bottlebrush with polypeptide as backbone was synthesized using graft-onto strategy. Poly(gamma-propargyl-L-glutamate) (PPLG) as backbone was firstly synthesized via ring-opening polymerization (ROP) of gamma-propargyl-L-glutamate (PLG) N-carboxyanhydride (NCA). Next, polystyrene-N-3 (PS-N-3) and monomethoxy poly(ethylene glycol)-N-3 (mPEG-N-3) as side chains were grafted onto the PPLG backbone using copper-catalyzed click reaction, which afforded good grafting density and efficiency. Two polypeptide bottlebrushes with PS-to-mPEG molar ratio at 70/30 and 30/70 were prepared. The self-assembly behaviors of these two polypeptide bottlebrushes were investigated using the cosolvent method, and their supramolecular structures were characterized using light scattering (LS) and electron microscopy.
语种	英语
出版者	INT UNION PURE APPLIED CHEMISTRY
WOS记录号	WOS:000311632000008
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/49641]
专题	中国科学院化学研究所
通讯作者	Li, Zhibo
作者单位	Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci BNLMS, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Luo, Chunhui,Chen, Chongyi,Li, Zhibo. Efficient synthesis and self-assembly of hetero-grafted amphiphilic polypepide bottlebrushes[J]. PURE AND APPLIED CHEMISTRY,2012,84(12):2569-2578.
APA	Luo, Chunhui,Chen, Chongyi,&Li, Zhibo.(2012).Efficient synthesis and self-assembly of hetero-grafted amphiphilic polypepide bottlebrushes.PURE AND APPLIED CHEMISTRY,84(12),2569-2578.
MLA	Luo, Chunhui,et al."Efficient synthesis and self-assembly of hetero-grafted amphiphilic polypepide bottlebrushes".PURE AND APPLIED CHEMISTRY 84.12(2012):2569-2578.