Structural Effect and Mechanism of C70-Carboxyfullerenes as Efficient Sensitizers against Cancer Cells

doi:10.1002/smll.201200158

CORC > 化学研究所 > 中国科学院化学研究所

	Structural Effect and Mechanism of C70-Carboxyfullerenes as Efficient Sensitizers against Cancer Cells
	Liu, Qiaoling 1; Guan, Mirong 2; Xu, Li 1; Shu, Chunying 1; Jin, Chan 3; Zheng, Junpeng 2; Fang, Xiaohong 1; Yang, Yongji 3; Wang, Chunru 1
刊名	SMALL
	2012-07-09
卷号	8 期号:13 页码:2070-2077
关键词	Cancer Therapy Fullerenes Membrane Blebbing Photodynamic Therapy Photosensitizers
ISSN号	1613-6810
DOI	10.1002/smll.201200158
英文摘要	Carboxyfullerenes with different adduct numbers and cage sizes are tested as photosensitizers for photodynamic therapy (PDT). The photodynamic efficiency of these carboxyfullerenes depends mainly on the cage size, C60 versus C70, and to a lesser extent on the adduct numbers. In particular, malonic acid modified C70 fullerenes are more efficient than their C60 counterparts as photosensitizers, and the mechanism of cell death induced by C70-carboxyfullerene under light irradiation is investigated in detail. The results indicate that cell death occurs via necrosis accompanied by membrane blebbing, which is a unique phenomenon for photosensitizer-induced cell death. Since C70-carboxyfullerene displays an efficient PDT property and negligible dark cytotoxicity, it is promising for use in PDT applications, especially in vascular capillary diseases usually occurring under the surface.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000306011500015
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/49529]
专题	中国科学院化学研究所
通讯作者	Shu, Chunying
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing Natl Lab Mol Sci, Key Lab Mol Nanostruct & Nanotechnol,Inst Chem, Beijing 100049, Peoples R China 3.Second Mil Med Univ, Inst Biophys, Shanghai 200433, Peoples R China
推荐引用方式 GB/T 7714	Liu, Qiaoling,Guan, Mirong,Xu, Li,et al. Structural Effect and Mechanism of C70-Carboxyfullerenes as Efficient Sensitizers against Cancer Cells[J]. SMALL,2012,8(13):2070-2077.
APA	Liu, Qiaoling.,Guan, Mirong.,Xu, Li.,Shu, Chunying.,Jin, Chan.,...&Wang, Chunru.(2012).Structural Effect and Mechanism of C70-Carboxyfullerenes as Efficient Sensitizers against Cancer Cells.SMALL,8(13),2070-2077.
MLA	Liu, Qiaoling,et al."Structural Effect and Mechanism of C70-Carboxyfullerenes as Efficient Sensitizers against Cancer Cells".SMALL 8.13(2012):2070-2077.