An Improved Approach to Poly(Ester-Carbonate) Conjugates

doi:10.1163/092050610X551952

CORC > 化学研究所 > 中国科学院化学研究所

	An Improved Approach to Poly(Ester-Carbonate) Conjugates
	Mo, Guojun 1,2; Yue, Jun 1,2; Ma, Ping'an 1; Huang, Yubin 1; Chen, Xuesi 1; Jing, Xiabin 1
刊名	JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
	2012
卷号	23 期号:1-4 页码:375-389
关键词	Poly(Ester-carbonate) Lactide Propylene Carbonate Pendant Carboxyl Groups 4-nitrophenol Aminolysis
ISSN号	0920-5063
DOI	10.1163/092050610X551952
英文摘要	A novel poly(ester-carbonate) (P(LA-co-NPC)) with activated pendant carboxyl groups was synthesized by ring-opening polymerization of L-lactide (LA) and 2-methyl-2-(4-nitrophenoxycarbonyl)-propylene carbonate (NPC) with diethyl zinc (ZnEt2) as catalyst. GPC and NMR studies confirmed the co-polymer structure. The pendant 4-nitrophenyl carboxylate groups can react with amino-containing molecules, such as 3,6,9-trioxa-1,11-undecanediamine, doxorubicin and chitosan under mild conditions. Therefore, any amino-containing molecules of biomedical interests can be conjugated to P(LA-co-NPC) efficiently and easily. The biocompatibility of the co-polymer was tested using L929 cell line, indicating that P(LA-co-NPC) is a promising biomedical material. (C) Koninklijke Brill NV, Leiden, 2012
语种	英语
出版者	VSP BV
WOS记录号	WOS:000297809800021
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/48325]
专题	中国科学院化学研究所
通讯作者	Jing, Xiabin
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Mo, Guojun,Yue, Jun,Ma, Ping'an,et al. An Improved Approach to Poly(Ester-Carbonate) Conjugates[J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,2012,23(1-4):375-389.
APA	Mo, Guojun,Yue, Jun,Ma, Ping'an,Huang, Yubin,Chen, Xuesi,&Jing, Xiabin.(2012).An Improved Approach to Poly(Ester-Carbonate) Conjugates.JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,23(1-4),375-389.
MLA	Mo, Guojun,et al."An Improved Approach to Poly(Ester-Carbonate) Conjugates".JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 23.1-4(2012):375-389.