The development of charge detection-quadrupole ion trap mass spectrometry driven by rectangular and triangular waves

doi:10.1039/c2an15756j

CORC > 化学研究所 > 中国科学院化学研究所

	The development of charge detection-quadrupole ion trap mass spectrometry driven by rectangular and triangular waves
	Xiong, Caiqiao 1,2; Xu, Gaoping 3; Zhou, Xiaoyu 1,2; Wang, Jianing 1,2; Tang, Yin 1,2; Chen, Rui 1,2; Peng, Wen-Ping 4; Chang, Huan-Cheng 5; Nie, Zongxiu 1,2,6
刊名	ANALYST
	2012
卷号	137 期号:5 页码:1199-1204
ISSN号	0003-2654
DOI	10.1039/c2an15756j
英文摘要	In this article, the charge detection quadrupole mass spectrometry (CD-ITMS) driven by rectangular and triangular waveforms (rect-CD-ITMS and tri-CD-ITMS) was developed for the characterization of microparticles. Since the frequency scan of rectangular and triangular waveform could be realized easier than that of sinusoidal waveform, this research intends to provide simpler operation modes for CD-ITMS. In order to demonstrate the feasibility of rect-CD-ITMS and tri-CD-ITMS, the discharge onset voltage, ejection point of analyzed particles, and the achieved mass resolution were analyzed and compared with the case in conventional sinusoidal CD-ITMS (sin-CD-ITMS). The results indicated that the rect-CD-ITMS and tri-CD-ITMS can work well for the mass measurement of microparticles by using frequency scan. Identical mass resolutions were achieved under the same root mean square (RMS) voltage of different waveforms. The mass resolution was further improved by increasing the applied voltage and signal-to-noise ratio (S/N) of charge detector. Moreover, the rect-CD-ITMS and tri-CD-ITMS were applied to characterize red blood cells (RBCs). According to the obtained mean masses and mass distributions, normal and anemic RBCs were distinguished successfully.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000300038400021
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/48259]
专题	中国科学院化学研究所
通讯作者	Nie, Zongxiu
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 2.Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Jiujiang Univ, Sch Sci, Jiujiang 332005, Peoples R China 4.Natl Dong Hwa Univ, Dept Phys, Shoufeng 97401, Hualien, Taiwan 5.Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan 6.Beijing Ctr Mass Spectrometry, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Xiong, Caiqiao,Xu, Gaoping,Zhou, Xiaoyu,et al. The development of charge detection-quadrupole ion trap mass spectrometry driven by rectangular and triangular waves[J]. ANALYST,2012,137(5):1199-1204.
APA	Xiong, Caiqiao.,Xu, Gaoping.,Zhou, Xiaoyu.,Wang, Jianing.,Tang, Yin.,...&Nie, Zongxiu.(2012).The development of charge detection-quadrupole ion trap mass spectrometry driven by rectangular and triangular waves.ANALYST,137(5),1199-1204.
MLA	Xiong, Caiqiao,et al."The development of charge detection-quadrupole ion trap mass spectrometry driven by rectangular and triangular waves".ANALYST 137.5(2012):1199-1204.