Cinchona Alkaloid Catalyzed Regio- and Enantioselective Allylic Amination of Morita-Baylis-Hillman Carbonates with Isatins

doi:10.1002/ejoc.201200376

CORC > 化学研究所 > 中国科学院化学研究所

	Cinchona Alkaloid Catalyzed Regio- and Enantioselective Allylic Amination of Morita-Baylis-Hillman Carbonates with Isatins
	Zhao, Mei-Xin 1,2,3; Chen, Ming-Xiao 1,2; Tang, Wen-Hao 1,2; Wei, Deng-Ke 1,2; Dai, Tong-Lei 1,2; Shi, Min 1,2,4
刊名	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
	2012-07-01
期号	19 页码:3598-3606
关键词	Organocatalysis Amination Alkaloids Allylic Compounds Isatins Carbonates
ISSN号	1434-193X
DOI	10.1002/ejoc.201200376
英文摘要	An efficient enantioselective allylic amination of MoritaBaylisHillman (MBH) carbonates derived from methyl acrylate and aromatic aldehydes with isatins has been realized in the presence of commercially available cinchona alkaloids. The allylic amination products were obtained in moderate-to-good yields (4674?%) with moderate-to-good enantioselectivities (up to 89?% ee) under mild conditions. The synthetic utility of the amination products has been well demonstrated by the facile synthesis of methyl (3R,4R)-10-oxo-4-phenyl-2,3,4,10-tetrahydropyrimido[1,2-a]indole-3-carboxylate.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000305510400008
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/48003]
专题	中国科学院化学研究所
通讯作者	Zhao, Mei-Xin
作者单位	1.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China 2.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Mei-Xin,Chen, Ming-Xiao,Tang, Wen-Hao,et al. Cinchona Alkaloid Catalyzed Regio- and Enantioselective Allylic Amination of Morita-Baylis-Hillman Carbonates with Isatins[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2012(19):3598-3606.
APA	Zhao, Mei-Xin,Chen, Ming-Xiao,Tang, Wen-Hao,Wei, Deng-Ke,Dai, Tong-Lei,&Shi, Min.(2012).Cinchona Alkaloid Catalyzed Regio- and Enantioselective Allylic Amination of Morita-Baylis-Hillman Carbonates with Isatins.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(19),3598-3606.
MLA	Zhao, Mei-Xin,et al."Cinchona Alkaloid Catalyzed Regio- and Enantioselective Allylic Amination of Morita-Baylis-Hillman Carbonates with Isatins".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .19(2012):3598-3606.