Biodegradable Amphiphilic Copolymer Containing Nucleobase: Synthesis, Self-Assembly in Aqueous Solutions, and Potential Use in Controlled Drug Delivery

doi:10.1021/bm301169x

CORC > 化学研究所 > 中国科学院化学研究所

	Biodegradable Amphiphilic Copolymer Containing Nucleobase: Synthesis, Self-Assembly in Aqueous Solutions, and Potential Use in Controlled Drug Delivery
	Kuang, Huihui 2,3; Wu, Suhong 2,3; Xie, Zhigang 2; Meng, Fanbo 1; Jing, Xiabin 2; Huang, Yubin 2
刊名	BIOMACROMOLECULES
	2012-09-01
卷号	13 期号:9 页码:3004-3012
ISSN号	1525-7797
DOI	10.1021/bm301169x
英文摘要	Biodegradable nucleobase-grafted amphiphilic copolymer, the methoxyl poly (ethylene glycol)-b-poly (L-lactide-omega-2-methyl-2(3-(2,3-dihydroxylpropylthio) propyloxycarbonyl)-propylene carbonate/1-carboxymethylthymine) (mPEG-b- P(LA-co-MPT)), was synthesized. H-1 NMR titration and FT-IR spectroscopy indicated that the hydrogen-bonding could be formed between mPEG-b-P(LA-co-MPT) and 9-hexadecyladenine (A-C16). The hydrophobic microenvironment of the amphiphilic copolymer can protect the complementary multiple hydrogen bonds between mPEG-b-P(LA-co-MPT) and A-C16 from water effectively. The addition of A-C16 not only lowered the critical aggregation concentration (CAC) of mPEG-b-P(LA-co-MPT)/A-C16 nanoparticles (NPs) in aqueous solution but also induced different morphologies, which can be observed by transmission electron microscopy (TEM). Meanwhile, dynamic light scattering (DLS) and turbidometry was utilized to evaluate the effect of temperature and pH change on the stability of mPEG-b-P(LA-co-MPT)/A-C16 NPs. Cytotoxicity evaluation showed good biocompatibility of the mPEG-b-P(LA-co-MPT)/A-C16 NPs. The in vitro drug release profile showed that with the increase of A-C16 content, the doxorubiucin (DOX) release at pH 7.4 decreased, while the faster release rate was observed with the addition of A-C16 with a pH of 5.0. Importantly, DOX-loaded NPs exerted comparable cytotoxicity against MDA-MB-231 cells. This work provided a new method to stabilize NP structure using hydrogen-bonds and would have the potential to be applied in controlled drug delivery.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000308508500044
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/47867]
专题	中国科学院化学研究所
通讯作者	Meng, Fanbo
作者单位	1.Jilin Univ, China Japan Union Hosp, Dept Cardiol, Changchun 130033, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Kuang, Huihui,Wu, Suhong,Xie, Zhigang,et al. Biodegradable Amphiphilic Copolymer Containing Nucleobase: Synthesis, Self-Assembly in Aqueous Solutions, and Potential Use in Controlled Drug Delivery[J]. BIOMACROMOLECULES,2012,13(9):3004-3012.
APA	Kuang, Huihui,Wu, Suhong,Xie, Zhigang,Meng, Fanbo,Jing, Xiabin,&Huang, Yubin.(2012).Biodegradable Amphiphilic Copolymer Containing Nucleobase: Synthesis, Self-Assembly in Aqueous Solutions, and Potential Use in Controlled Drug Delivery.BIOMACROMOLECULES,13(9),3004-3012.
MLA	Kuang, Huihui,et al."Biodegradable Amphiphilic Copolymer Containing Nucleobase: Synthesis, Self-Assembly in Aqueous Solutions, and Potential Use in Controlled Drug Delivery".BIOMACROMOLECULES 13.9(2012):3004-3012.