Conjugated Polymer Nanoparticles for Light-Activated Anticancer and Antibacterial Activity with Imaging Capability

doi:10.1021/la203832h

CORC > 化学研究所 > 中国科学院化学研究所

	Conjugated Polymer Nanoparticles for Light-Activated Anticancer and Antibacterial Activity with Imaging Capability
	Chong, Hui; Nie, Chenyao; Zhu, Chunlei; Yang, Qiong; Liu, Libing; Lv, Fengting; Wang, Shu
刊名	LANGMUIR
	2012-01-31
卷号	28 期号:4 页码:2091-2098
ISSN号	0743-7463
DOI	10.1021/la203832h
英文摘要	A new water-soluble conjugated polymer containing fluorene and boron-dipyrromethene repeat units in the backbones (PBF) that exhibits red emission was synthesized and characterized. Cationic PBF forms uniform nanoparticles with negatively charged disodium salt 3,3'-dithiodipropionic acid (SDPA) in aqueous solution through electrostatic interactions. The nanoparticles display absorption maximum at 550 nm and emission maximum at 590 rim. Upon photoexcitation with white light (400-800 nm) with 90 and 45 mW . cm(-2) for bacteria and cancer cells killing respectively, PBF nanoparticles can sensitize the oxygen molecule to readily produce reactive oxygen species (ROS) for rapidly killing neighboring bacteria and cancer cells. Furthermore, PBF nanoparticles concurrently provide optical imaging capability. PBF nanoparticles are therefore a promising multifunctional material for treating cancers and bacteria infections, while concurrently providing optical monitoring capabilities.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000300466100021
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/47723]
专题	中国科学院化学研究所
通讯作者	Yang, Qiong
作者单位	Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Organ Solids, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Chong, Hui,Nie, Chenyao,Zhu, Chunlei,et al. Conjugated Polymer Nanoparticles for Light-Activated Anticancer and Antibacterial Activity with Imaging Capability[J]. LANGMUIR,2012,28(4):2091-2098.
APA	Chong, Hui.,Nie, Chenyao.,Zhu, Chunlei.,Yang, Qiong.,Liu, Libing.,...&Wang, Shu.(2012).Conjugated Polymer Nanoparticles for Light-Activated Anticancer and Antibacterial Activity with Imaging Capability.LANGMUIR,28(4),2091-2098.
MLA	Chong, Hui,et al."Conjugated Polymer Nanoparticles for Light-Activated Anticancer and Antibacterial Activity with Imaging Capability".LANGMUIR 28.4(2012):2091-2098.