Effects of aggregation and the surface properties of gold nanoparticles on cytotoxicity and cell growth

doi:10.1016/j.nano.2011.05.005

CORC > 化学研究所 > 中国科学院化学研究所

	Effects of aggregation and the surface properties of gold nanoparticles on cytotoxicity and cell growth
	Cui, Wenjuan; Li, Jinru; Zhang, Yakun; Rong, Huilin; Lu, Wensheng; Jiang, Long
刊名	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
	2012
卷号	8 期号:1 页码:46-53
关键词	Nanoparticles Hela Cell Escherichia Coli Cytotoxicity Inkjet Printing
ISSN号	1549-9634
DOI	10.1016/j.nano.2011.05.005
英文摘要	The effect of gold nanoparticles (Au NPs) on cells remains open for investigation. Here we show that small Au NPs can be endocytosed by cells and form aggregates inside the cell, resulting in cytotoxicity. When the aggregates become too large to enter the cell and instead adhere onto the cell surface, however, the growth rate of HeLa cells increases. Printed patterns of Au NPs fabricated through inkjet printing technology were used to study the effects of Au NP aggregation on human cervical carcinoma (HeLa) cell activity. The growth of the HeLa cells was inhibited on the polymer-coated Au NPs but increased on the silicon substrate. On the uncoated Au NP surface, however, the HeLa cell growth rate was higher than that on the silicon substrate. Experiments with Escherichia coli cells showed a similar effect of the Au NPs. This phenomenon provides a new perspective for research on toxicity in nanoparticle biology.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000299010500007
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/47515]
专题	中国科学院化学研究所
通讯作者	Jiang, Long
作者单位	Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Colloids & Surfaces, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Cui, Wenjuan,Li, Jinru,Zhang, Yakun,et al. Effects of aggregation and the surface properties of gold nanoparticles on cytotoxicity and cell growth[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2012,8(1):46-53.
APA	Cui, Wenjuan,Li, Jinru,Zhang, Yakun,Rong, Huilin,Lu, Wensheng,&Jiang, Long.(2012).Effects of aggregation and the surface properties of gold nanoparticles on cytotoxicity and cell growth.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,8(1),46-53.
MLA	Cui, Wenjuan,et al."Effects of aggregation and the surface properties of gold nanoparticles on cytotoxicity and cell growth".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 8.1(2012):46-53.