Assembled Hemoglobin and Catalase Nanotubes for the Treatment of Oxidative Stress

doi:10.1021/jp407164q

CORC > 化学研究所 > 中国科学院化学研究所

	Assembled Hemoglobin and Catalase Nanotubes for the Treatment of Oxidative Stress
	Chen, Bo; Jia, Yi; Zhao, Jie; Li, Hong; Dong, Weiguang; Li, Junbai
刊名	JOURNAL OF PHYSICAL CHEMISTRY C
	2013-09-26
卷号	117 期号:38 页码:19751-19758
ISSN号	1932-7447
DOI	10.1021/jp407164q
英文摘要	Hemoglobin-based nanotubes for the treatment of oxidative stress are successfully fabricated via covalent layer-by-layer assembly. Catalase, the most efficient enzyme for scavenging the hydrogen peroxide (H2O2), is embedded into the inner pores of the hemoglobin/dialdehyde heparin (Hb/DHP)(5) nanotubes via covalent bonding to protect the delicate enzyme from inactivation after the removal of the polycarbonate (PC) template. Dialdehyde heparin (DHP) as wall components is a cross-linker. The biocompatibility and capabilities of the nanotubes to protect the cells under oxidative stress are characterized with the Cell Counting Kit-8 (CCK-8). The scavenging capabilities of four kinds of autofluorescent nanotubes are tested through the reaction with H2O2 by the measurement of the UV-vis absorbance at 240 nm. All the experimental results show that the assembled hemoglobin-based nanotubes possess H2O2-scavenging capacity as well as biocompatibility, indicating the potential application in the treatment of oxidative stress.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000330162500057
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/46911]
专题	中国科学院化学研究所
通讯作者	Li, Junbai
作者单位	Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Colloid & Interface Sci, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Chen, Bo,Jia, Yi,Zhao, Jie,et al. Assembled Hemoglobin and Catalase Nanotubes for the Treatment of Oxidative Stress[J]. JOURNAL OF PHYSICAL CHEMISTRY C,2013,117(38):19751-19758.
APA	Chen, Bo,Jia, Yi,Zhao, Jie,Li, Hong,Dong, Weiguang,&Li, Junbai.(2013).Assembled Hemoglobin and Catalase Nanotubes for the Treatment of Oxidative Stress.JOURNAL OF PHYSICAL CHEMISTRY C,117(38),19751-19758.
MLA	Chen, Bo,et al."Assembled Hemoglobin and Catalase Nanotubes for the Treatment of Oxidative Stress".JOURNAL OF PHYSICAL CHEMISTRY C 117.38(2013):19751-19758.