Multifunctional gadofulleride nanoprobe for magnetic resonance imaging/fluorescent dual modality molecular imaging and free radical scavenging

doi:10.1016/j.carbon.2013.08.011

CORC > 化学研究所 > 中国科学院化学研究所

	Multifunctional gadofulleride nanoprobe for magnetic resonance imaging/fluorescent dual modality molecular imaging and free radical scavenging
	Zheng, Jun-peng 1; Zhen, Ming-Ming 1; Ge, Jie-Chao 2; Liu, Qiao-Ling 1; Jiang, Feng 1; Shu, Chun-Ying 1; Alhadlaq, Hisham A.3,4; Wang, Chun-Ru 1
刊名	CARBON
	2013-12-01
卷号	65 页码:175-180
ISSN号	0008-6223
DOI	10.1016/j.carbon.2013.08.011
英文摘要	Strategic design of gadofullerene derivatives is critical to integrate multifunctionality into one entity. Herein, an easy method was developed to fabricate a new type of magnetic resonance imaging/fluorescent integrative molecular imaging probe based on Gd@C-82. The functionalized gadofulleride Gd@C82O similar to 14(OH)(similar to 14)(NH2)(similar to 6) not only exhibits an order of magnitude larger relaxivity (47.0 +/- 0.8 mM(-1) s(-1) at 0.5 T) than commercially used gadopentetic acid (4.5 +/- 0.1 mM(-1) s(-1)) under the same condition and multi-wavelength emission features derived from the multi-wavelength excitation for dual-modality diagnosis, but also highly efficient scavenging capability toward hydroxyl radicals. (C) 2013 Elsevier Ltd. All rights reserved.
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000326773200020
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/46779]
专题	中国科学院化学研究所
通讯作者	Wang, Chun-Ru
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China 3.King Saud Univ, Dept Phys & Astron, Riyadh 11451, Saudi Arabia 4.King Saud Univ, King Abdullah Inst Nanotechnol, Riyadh 11451, Saudi Arabia
推荐引用方式 GB/T 7714	Zheng, Jun-peng,Zhen, Ming-Ming,Ge, Jie-Chao,et al. Multifunctional gadofulleride nanoprobe for magnetic resonance imaging/fluorescent dual modality molecular imaging and free radical scavenging[J]. CARBON,2013,65:175-180.
APA	Zheng, Jun-peng.,Zhen, Ming-Ming.,Ge, Jie-Chao.,Liu, Qiao-Ling.,Jiang, Feng.,...&Wang, Chun-Ru.(2013).Multifunctional gadofulleride nanoprobe for magnetic resonance imaging/fluorescent dual modality molecular imaging and free radical scavenging.CARBON,65,175-180.
MLA	Zheng, Jun-peng,et al."Multifunctional gadofulleride nanoprobe for magnetic resonance imaging/fluorescent dual modality molecular imaging and free radical scavenging".CARBON 65(2013):175-180.