Functionalized polypropylene non-woven fabric membrane with bovine serum albumin and its hemocompatibility enhancement

doi:10.1016/j.colsurfb.2012.08.007

CORC > 化学研究所 > 中国科学院化学研究所

	Functionalized polypropylene non-woven fabric membrane with bovine serum albumin and its hemocompatibility enhancement
	Zhang, Chang 1,2; Jin, Jing 1,2; Zhao, Jie 1; Jiang, Wei 1; Yin, Jinghua 1
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2013-02-01
卷号	102 页码:45-52
关键词	Hemocompatibility Surface Modification Polypropylene Non-woven Fabric Membrane Uv-irradiated Poly(Acrylic Acid) Bovine Serum Albumin
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2012.08.007
英文摘要	Bovine serum albumin (BSA) was successfully immobilized onto polypropylene non-woven fabric (PPNWF) membranes using poly(acrylic acid) (PAA) as a spacer. Firstly, O-2 plasma treatment and UV-irradiated technique were combined to graft PM onto the membranes. BSA was then immobilized onto the PAA grafted surface through the coupling of amino groups of BSA to the carboxyl groups of PM. The immobilization of PM and BSA onto the membrane was confirmed by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), and water contact angle measurement. The water contact angle measurement results revealed that the membrane hydrophilicity improved after modification with PAA and BSA. After BSA immobilization, the amount of protein adsorption and the number of platelet adhesion on the modified membrane significantly decreased, which indicated that hemocompatibility had been considerably improved compared with neat and PM grafted PPNWF. The whole blood clotting time measurement showed that the anticoagulant property of the modified membrane was also significantly enhanced. Crown Copyright (c) 2012 Published by Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000313301200007
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/46663]
专题	中国科学院化学研究所
通讯作者	Jiang, Wei
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Chang,Jin, Jing,Zhao, Jie,et al. Functionalized polypropylene non-woven fabric membrane with bovine serum albumin and its hemocompatibility enhancement[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2013,102:45-52.
APA	Zhang, Chang,Jin, Jing,Zhao, Jie,Jiang, Wei,&Yin, Jinghua.(2013).Functionalized polypropylene non-woven fabric membrane with bovine serum albumin and its hemocompatibility enhancement.COLLOIDS AND SURFACES B-BIOINTERFACES,102,45-52.
MLA	Zhang, Chang,et al."Functionalized polypropylene non-woven fabric membrane with bovine serum albumin and its hemocompatibility enhancement".COLLOIDS AND SURFACES B-BIOINTERFACES 102(2013):45-52.