Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation

doi:10.1002/mabi.201300012

CORC > 化学研究所 > 中国科学院化学研究所

	Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation
	Li, Bin 1,2; Li, Taihang 3; Chen, Gao 1,2; Li, Xiaoyuan 1; Yan, Lesan 1,2; Xie, Zhigang 1; Jing, Xiabin 1; Huang, Yubin 1
刊名	MACROMOLECULAR BIOSCIENCE
	2013-07-01
卷号	13 期号:7 页码:893-902
关键词	Biocompatibility Chain Sequences Hemoglobin Isoelectric Aggregation Micelles
ISSN号	1616-5187
DOI	10.1002/mabi.201300012
英文摘要	Amphiphilic triblock copolymers with carbonyl groups located either in the middle segment or in the third side block are synthesized by adjusting feeding sequence of the comonomers. The conjugation of hemoglobin (Hb) on the copolymer micelles is realized by condensation reactions of carbonyl with the amino groups of Hb, and the gas-binding capacity of Hb is well preserved. Interestingly, the reassembly behavior of Hb-conjugated micelles (HbM) is explored by adjusting the pH. As for triblock copolymers with a carbonyl-functionalized segment as the third block, Hb is rearranged into the inner core of micelles when the pH is adjusted close to the isoelectric point of Hb. Therefore, it may provide a new needed route for fabrication of protein carriers, which is different from the traditional encapsulation technique.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000327814500008
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/46535]
专题	中国科学院化学研究所
通讯作者	Li, Taihang
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Zhejiang Hisun Pharmaceut Co Ltd, Taizhou 318000, Peoples R China
推荐引用方式 GB/T 7714	Li, Bin,Li, Taihang,Chen, Gao,et al. Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation[J]. MACROMOLECULAR BIOSCIENCE,2013,13(7):893-902.
APA	Li, Bin.,Li, Taihang.,Chen, Gao.,Li, Xiaoyuan.,Yan, Lesan.,...&Huang, Yubin.(2013).Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation.MACROMOLECULAR BIOSCIENCE,13(7),893-902.
MLA	Li, Bin,et al."Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation".MACROMOLECULAR BIOSCIENCE 13.7(2013):893-902.