Protective Effect of C-70-Carboxyfullerene against Oxidative-Induced Stress on Postmitotic Muscle Cells

doi:10.1021/am400535j

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	Protective Effect of C-70-Carboxyfullerene against Oxidative-Induced Stress on Postmitotic Muscle Cells
	Liu, Qiaoling; Zheng, Junpeng; Guan, Mirong; Fang, Xiaohong; Wang, Chunru; Shu, Chunying
刊名	ACS APPLIED MATERIALS & INTERFACES
	2013-05-22
卷号	5 期号:10 页码:4328-4333
关键词	Carboxyfullerene Oxidative Stress Chemical Structure Cytoprotective Capability C2c12 Cell
ISSN号	1944-8244
DOI	10.1021/am400535j
英文摘要	Satellite muscle cells play an important role in regeneration of skeletal muscle. However, they are particularly vulnerable to oxidative stress. Herein, we address our efforts on the cytoprotective activities of carboxyfullerenes with different cage size (C-60 vs C-70) and adduct number on postmitotic muscle cell (C2C12 cell). The correlation of the structural effect on the cytoprotective capability of carboxyfullerenes was evaluated. We find that quadrimalonic acid C-70 fullerene (QF(70)) exhibits higher capability on protecting cells from oxidative-induced stress among these tested carboxyfullerenes. The accumulation of intracellular superoxide dismutase (SOD) is proposed to play an important role in their diverse antioxidative ability. Moreover, the pretreatment of QF(70) could also obviously enhance the viability of myotubes originated from oxidative-stressed C2C12 cells, which facilitates the future application of carboxyfullerenes in tissue engineering and nanomedicine.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000319551200047
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/46441]
专题	中国科学院化学研究所
通讯作者	Fang, Xiaohong
作者单位	Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Liu, Qiaoling,Zheng, Junpeng,Guan, Mirong,et al. Protective Effect of C-70-Carboxyfullerene against Oxidative-Induced Stress on Postmitotic Muscle Cells[J]. ACS APPLIED MATERIALS & INTERFACES,2013,5(10):4328-4333.
APA	Liu, Qiaoling,Zheng, Junpeng,Guan, Mirong,Fang, Xiaohong,Wang, Chunru,&Shu, Chunying.(2013).Protective Effect of C-70-Carboxyfullerene against Oxidative-Induced Stress on Postmitotic Muscle Cells.ACS APPLIED MATERIALS & INTERFACES,5(10),4328-4333.
MLA	Liu, Qiaoling,et al."Protective Effect of C-70-Carboxyfullerene against Oxidative-Induced Stress on Postmitotic Muscle Cells".ACS APPLIED MATERIALS & INTERFACES 5.10(2013):4328-4333.