A reduction-sensitive carrier system using mesoporous silica nanospheres with biodegradable polyester as caps

doi:10.1039/c3cp51947c

CORC > 化学研究所 > 中国科学院化学研究所

	A reduction-sensitive carrier system using mesoporous silica nanospheres with biodegradable polyester as caps
	He, Hongyan 1,2; Kuang, Huihui 1,2; Yan, Lesan 1,2; Meng, Fanbo 3; Xie, Zhigang 1; Jing, Xiabin 1; Huang, Yubin 1
刊名	PHYSICAL CHEMISTRY CHEMICAL PHYSICS
	2013
卷号	15 期号:34 页码:14210-14218
ISSN号	1463-9076
DOI	10.1039/c3cp51947c
英文摘要	Mesoporous silica nanoparticles (MSN)-polymer hybrid combined with the aliphatic biodegradable polyester caps on the surface were first developed in order to manipulate the smart intracellular release of anticancer drugs. First, poly(ethylene glycol)-b-poly(epsilon-caprolactone) (PEG-PCL) was successfully grafted on the surface of MSN via disulfide bonds which could cleave under a reduction environment in tumor cells. The anticancer drug doxorubicin (DOX) was encapsulated into the particle pores. The in vitro drug release profile showed that DOX release was significantly restricted by the polymer caps at pH 7.4, while it was greatly accelerated upon the addition of GSH. Cytotoxicity evaluation showed good biocompatibility with the hybrid particles. Fast endocytosis and intracellular DOX release were observed by confocal laser scanning microscopy (CLSM). The DOX-loaded particles exhibited comparable antitumor activity with free DOX towards HeLa cells and showed in a time-dependent manner. This work developed an extensive method of utilizing aliphatic biodegradable polyesters as polymer caps for MSN to control drug delivery. The paper might offer a potential option for cancer therapy.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000322725000008
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/46355]
专题	中国科学院化学研究所
通讯作者	Meng, Fanbo
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Jilin Univ, China Japan Union Hosp, Dept Cardiol, Changchun 130033, Peoples R China
推荐引用方式 GB/T 7714	He, Hongyan,Kuang, Huihui,Yan, Lesan,et al. A reduction-sensitive carrier system using mesoporous silica nanospheres with biodegradable polyester as caps[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2013,15(34):14210-14218.
APA	He, Hongyan.,Kuang, Huihui.,Yan, Lesan.,Meng, Fanbo.,Xie, Zhigang.,...&Huang, Yubin.(2013).A reduction-sensitive carrier system using mesoporous silica nanospheres with biodegradable polyester as caps.PHYSICAL CHEMISTRY CHEMICAL PHYSICS,15(34),14210-14218.
MLA	He, Hongyan,et al."A reduction-sensitive carrier system using mesoporous silica nanospheres with biodegradable polyester as caps".PHYSICAL CHEMISTRY CHEMICAL PHYSICS 15.34(2013):14210-14218.