Disassembly of Multicompartment Polymer Micelles in Spatial Sequence Using an Electrostatic Field and Its Application for Release in Chronological Order

doi:10.1002/anie.201712794

CORC > 化学研究所 > 中国科学院化学研究所

	Disassembly of Multicompartment Polymer Micelles in Spatial Sequence Using an Electrostatic Field and Its Application for Release in Chronological Order
	Wu, Ming 1,2; Zhu, Yutian 1; Jiang, Wei 1
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2018-03-26
卷号	57 期号:14 页码:3578-3582
关键词	Block Copolymers Kinetics Micelles Nanotechnology Self-assembly Release
ISSN号	1433-7851
DOI	10.1002/anie.201712794
英文摘要	Multicompartment micelles (MCPs), comprising sequences of repeated elemental discoid parts connected by fasciculus, were formed by self-assembly of polystyrene-block-poly(2-vinyl pyridine)-block-poly(ethylene oxide). Using an electrostatic field, the MCPs can be disassembled through consequent release of small spherical micelles. During this disassembly process, release of loaded species can be achieved from the micelles in chronological order. Two location-selected cargos (mitoxantrone (MTNT) and fluorescein isothiocyanate (FITC)) in the outer and inner compartments of the micelles can be released in chronological order. Under the applied electrostatic field (intensity: 16kVcm(-1)), the loaded MTNT was rapidly released with more than 80% release, whereas the loaded FITC was slowly released with less than 20% release in 12h. At a later stage (after more than 12h), the loaded MTNT was slowly released with less than 20% release, while the loaded FITC was rapidly released with more than 80% release.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000428350100003
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/46121]
专题	中国科学院化学研究所
通讯作者	Zhu, Yutian; Jiang, Wei
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wu, Ming,Zhu, Yutian,Jiang, Wei. Disassembly of Multicompartment Polymer Micelles in Spatial Sequence Using an Electrostatic Field and Its Application for Release in Chronological Order[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(14):3578-3582.
APA	Wu, Ming,Zhu, Yutian,&Jiang, Wei.(2018).Disassembly of Multicompartment Polymer Micelles in Spatial Sequence Using an Electrostatic Field and Its Application for Release in Chronological Order.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(14),3578-3582.
MLA	Wu, Ming,et al."Disassembly of Multicompartment Polymer Micelles in Spatial Sequence Using an Electrostatic Field and Its Application for Release in Chronological Order".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.14(2018):3578-3582.