A Versatile Method to Prepare Protein Nanoclusters for Drug Delivery

doi:10.1002/mabi.201700282

CORC > 化学研究所 > 中国科学院化学研究所

	A Versatile Method to Prepare Protein Nanoclusters for Drug Delivery
	Wang, Yupeng 1,2; Yan, Lesan 3; He, Shasha 1,2; Zhou, Dongfang 1; Cheng, Yanxiang 1; Chen, Xuesi 1; Jing, Xiabin 1; Huang, Yubin 1
刊名	MACROMOLECULAR BIOSCIENCE
	2018-02-01
卷号	18 期号:2
关键词	Autofluorescent Property Drug Delivery Isoelectric Point Protein Nanoclusters
ISSN号	1616-5187
DOI	10.1002/mabi.201700282
英文摘要	Nanocarriers based on natural biomaterials such as peptides and proteins have shown great advantages in the field of nanomedicine. However, the complicated preparation process and possible denaturation of proteins may limit their further applications. Herein, a novel method is developed to prepare protein nanocluster drug delivery system based on the self-aggregated property of proteins under the isoelectric point condition. The crosslinked protein nanoclusters, prepared by adding modified natural crosslinking agent polysaccharide, exhibit excellent stability and autofluorescent property in physiological conditions. Hemoglobin, a model protein, is chosen for preparation of drug-loaded nanoclusters. The as-prepared nanoclusters demonstrate a pH-responsive drug release behavior and can successfully deliver drugs into cancer cells. Moreover, this approach can be extended to various proteins, exemplifying the universal applicability of our new preparation method for protein-based nanoparticles.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000425026400006
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45749]
专题	中国科学院化学研究所
通讯作者	Zhou, Dongfang; Huang, Yubin
作者单位	1.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun Inst Appl Chem, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Penn, Sch Engn & Appl Sci, Dept Bioengn, Philadelphia, PA 19104 USA
推荐引用方式 GB/T 7714	Wang, Yupeng,Yan, Lesan,He, Shasha,et al. A Versatile Method to Prepare Protein Nanoclusters for Drug Delivery[J]. MACROMOLECULAR BIOSCIENCE,2018,18(2).
APA	Wang, Yupeng.,Yan, Lesan.,He, Shasha.,Zhou, Dongfang.,Cheng, Yanxiang.,...&Huang, Yubin.(2018).A Versatile Method to Prepare Protein Nanoclusters for Drug Delivery.MACROMOLECULAR BIOSCIENCE,18(2).
MLA	Wang, Yupeng,et al."A Versatile Method to Prepare Protein Nanoclusters for Drug Delivery".MACROMOLECULAR BIOSCIENCE 18.2(2018).