A dual-site simultaneous binding mode in the interaction between parallel-stranded G-quadruplex [d(TGGGGT)](4) and cyanine dye 2,2 '-diethyl-9-methyl-selenacarbocyanine bromide

doi:10.1093/nar/gks1328

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	A dual-site simultaneous binding mode in the interaction between parallel-stranded G-quadruplex [d(TGGGGT)](4) and cyanine dye 2,2 '-diethyl-9-methyl-selenacarbocyanine bromide
	Gai, Wei 1,2; Yang, Qianfan 1; Xiang, Junfeng 1; Jiang, Wei 1; Li, Qian 1; Sun, Hongxia 1,2; Guan, Aijiao 1,2; Shang, Qian 1; Zhang, Hong 1; Tang, Yalin 1
刊名	NUCLEIC ACIDS RESEARCH
	2013-02-01
卷号	41 期号:4 页码:2709-2722
ISSN号	0305-1048
DOI	10.1093/nar/gks1328
英文摘要	G-quadruplexes have attracted growing attention as a potential cancer-associated target for both treatment and detection in recent years. For detection purpose, high specificity is one of the most important factors to be considered in G-quadruplex probe design. It is well known that end stacking and groove binding are two dominated quadruplex-ligand binding modes, and currently most reported G-quadruplex probes are designed based on the former, which has been proven to show good selectivity between quadruplexes and non-quadruplexes. Because groove of G-quadruplex also has some unique chemical properties, it could be inferred that probes that can interact with both the groove and G-tetrad site of certain G-quadruplexes simultaneously might possess higher specificity in aspects of discriminating different quadruplexes. In this article, we report a cyanine dye as a potential novel probe scaffold that could occupy both the 5'-end external G-tetrad and the corresponding groove of the G-quadruplex simultaneously. By using various spectrum and nuclear magnetic resonance techniques, we give a detailed binding characterization for this dual-site simultaneous binding mode. A preliminary result suggests that this mode might provide highly specific recognition to a parallel-stranded G-quadruplex. These findings and the structural elucidation might give some clues in aspects of developing highly specific G-quadruplex probes.
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000318062000058
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/43349]
专题	中国科学院化学研究所
通讯作者	Tang, Yalin
作者单位	1.Chinese Acad Sci ICCAS, BNLMS, Ctr Mol Sci,Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Dept Chem, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Gai, Wei,Yang, Qianfan,Xiang, Junfeng,et al. A dual-site simultaneous binding mode in the interaction between parallel-stranded G-quadruplex [d(TGGGGT)](4) and cyanine dye 2,2 '-diethyl-9-methyl-selenacarbocyanine bromide[J]. NUCLEIC ACIDS RESEARCH,2013,41(4):2709-2722.
APA	Gai, Wei.,Yang, Qianfan.,Xiang, Junfeng.,Jiang, Wei.,Li, Qian.,...&Tang, Yalin.(2013).A dual-site simultaneous binding mode in the interaction between parallel-stranded G-quadruplex [d(TGGGGT)](4) and cyanine dye 2,2 '-diethyl-9-methyl-selenacarbocyanine bromide.NUCLEIC ACIDS RESEARCH,41(4),2709-2722.
MLA	Gai, Wei,et al."A dual-site simultaneous binding mode in the interaction between parallel-stranded G-quadruplex [d(TGGGGT)](4) and cyanine dye 2,2 '-diethyl-9-methyl-selenacarbocyanine bromide".NUCLEIC ACIDS RESEARCH 41.4(2013):2709-2722.