Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy

doi:10.1002/anie.201801378

CORC > 化学研究所 > 中国科学院化学研究所

	Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy
	Lian, Xizhen 1; Huang, Yanyan 2,3; Zhu, Yuanyuan 2,3; Fang, Yu 1; Zhao, Rui 2,3; Joseph, Elizabeth 1; Li, Jialuo 1; Pellois, Jean-Philippe 1,4; Zhou, Hong-Cai 1
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2018-05-14
卷号	57 期号:20 页码:5725-5730
关键词	Cancer Drug Delivery Enzymes Metal-organic Frameworks Nanoparticles
ISSN号	1433-7851
DOI	10.1002/anie.201801378
英文摘要	Prodrug activation, by exogenously administered enzymes, for cancer therapy is an approach to achieve better selectivity and less systemic toxicity than conventional chemotherapy. However, the short half-lives of the activating enzymes in the bloodstream has limited its success. Demonstrated here is that a tyrosinase-MOF nanoreactor activates the prodrug paracetamol in cancer cells in a long-lasting manner. By generating reactive oxygen species (ROS) and depleting glutathione (GSH), the product of the enzymatic conversion of paracetamol is toxic to drug-resistant cancer cells. Tyrosinase-MOF nanoreactors cause significant cell death in the presence of paracetamol for up to three days after being internalized by cells, while free enzymes totally lose activity in a few hours. Thus, enzyme-MOF nanocomposites are envisioned to be novel persistent platforms for various biomedical applications.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000431488200024
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/43283]
专题	中国科学院化学研究所
通讯作者	Zhou, Hong-Cai
作者单位	1.Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA 2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Chem, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 4.Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA
推荐引用方式 GB/T 7714	Lian, Xizhen,Huang, Yanyan,Zhu, Yuanyuan,et al. Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(20):5725-5730.
APA	Lian, Xizhen.,Huang, Yanyan.,Zhu, Yuanyuan.,Fang, Yu.,Zhao, Rui.,...&Zhou, Hong-Cai.(2018).Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(20),5725-5730.
MLA	Lian, Xizhen,et al."Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.20(2018):5725-5730.