Zincke's Salt-Substituted Tetraphenylethylenes for Fluorometric Turn-On Detection of Glutathione and Fluorescence Imaging of Cancer Cells

doi:10.1021/acsami.7b14446

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	Zincke's Salt-Substituted Tetraphenylethylenes for Fluorometric Turn-On Detection of Glutathione and Fluorescence Imaging of Cancer Cells
	Zhan, Chi 1,2; Zhang, Guanxin 1; Zhang, Deqing 1,2
刊名	ACS APPLIED MATERIALS & INTERFACES
	2018-04-18
卷号	10 期号:15 页码:12141-12149
关键词	Aggregation-induced Emission Tetraphenylethylene Zincke's Salt Glutathione Photodynamic Therapy
ISSN号	1944-8244
DOI	10.1021/acsami.7b14446
英文摘要	In this paper, we report Zincke's salt substituted tetraphenylethylenes la and lb with Cl- and PF6- as counteranions, respectively. The crystal structure of lb was determined. Both la and lb are almost nonemissive even in the aggregated states. This is attributed to the photoinduced electron transfer from 2,2-bis(4-methoxypheny1)-1-phenylvinyl-phenyl unit to 1-(2,4-dinitrophenyl) pyridinium unit within la and lb. The results demonstrate that the emissions of la and lb in aqueous solution can be switched on upon either reaction with GSH or light irradiation. On the basis of the reaction between la and GSH, la can be utilized for the fluorescence turn-on detection of GSH selectively, and GSH with concentration as low as 36.9 nM can be detected. The transformation of lb into 2 under light irradiation results in the fluorescence imaging of Hela and U2OS cells and phototoxicity toward Hela and U2OS cells after the protonation of pyridine unit in 2 because of the acidic environment of tumor cells. Aggregates of lb can be up-taken by Hela and U2OS cells and fluorescence imaging has been successfully recorded with CLSM. Moreover, the protonated form of 2 can function as photosensitizer and lb shows phototoxicity toward tumor cells such as Hela and U2OS cells.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000430642100007
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/43187]
专题	中国科学院化学研究所
通讯作者	Zhang, Guanxin; Zhang, Deqing
作者单位	1.Chinese Acad Sci, Inst Chem, CAS Res Educ Ctr Excellence Mol Sci, CAS Key Lab Organ Solids, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhan, Chi,Zhang, Guanxin,Zhang, Deqing. Zincke's Salt-Substituted Tetraphenylethylenes for Fluorometric Turn-On Detection of Glutathione and Fluorescence Imaging of Cancer Cells[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(15):12141-12149.
APA	Zhan, Chi,Zhang, Guanxin,&Zhang, Deqing.(2018).Zincke's Salt-Substituted Tetraphenylethylenes for Fluorometric Turn-On Detection of Glutathione and Fluorescence Imaging of Cancer Cells.ACS APPLIED MATERIALS & INTERFACES,10(15),12141-12149.
MLA	Zhan, Chi,et al."Zincke's Salt-Substituted Tetraphenylethylenes for Fluorometric Turn-On Detection of Glutathione and Fluorescence Imaging of Cancer Cells".ACS APPLIED MATERIALS & INTERFACES 10.15(2018):12141-12149.