Surface plasmon resonance sensing with adjustable sensitivity based on a flexible liquid core coupling unit

doi:10.1016/j.talanta.2018.03.040

CORC > 化学研究所 > 中国科学院化学研究所

	Surface plasmon resonance sensing with adjustable sensitivity based on a flexible liquid core coupling unit
	Xu, Jiying 1; Chen, Yi 1,2
刊名	TALANTA
	2018-07-01
卷号	184 页码:468-474
关键词	Surface Plasmon Resonance Liquid Core Coupling Signal Amplification Adjustable Sensitivity Carcinoembryonic Antigen (Cea)
ISSN号	0039-9140
DOI	10.1016/j.talanta.2018.03.040
英文摘要	The signal amplification methods of surface plasmon resonance (SPR) are mainly with sample selectivity. Herein proposed is a liquid core coupling SPR sensing method with adjustable sensitivity and universal applicability. A liquid core coupling unit and based on which a wavelength interrogation SPR sensor have been designed and constructed, in which a conventional chip could be used with an ingenious design and the sensitivity can be adjusted by changing the liquid core refractive index. The experimental data revealed that the sensitivity can be enhanced for 7.8 times by decreasing the liquid core refractive index from 1.5174 to 1.4502. The real applicability was validated by determination of carcinoembryonic antigen (CEA) with the signal intensity of the early stage colon cancer patient clearly up-regulated for nearly 18 folds compared with the healthy. It exhibited an adequate sensitivity, and further considering its simplicity avoiding the troublesome analysis process and/or chip preparing procedure, and extendibility to SPR imaging, the proposed method would be promising for medical diagnostics, food safety, environmental monitoring, and so on.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000432234900060
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/42777]
专题	中国科学院化学研究所
通讯作者	Xu, Jiying; Chen, Yi
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 2.Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Xu, Jiying,Chen, Yi. Surface plasmon resonance sensing with adjustable sensitivity based on a flexible liquid core coupling unit[J]. TALANTA,2018,184:468-474.
APA	Xu, Jiying,&Chen, Yi.(2018).Surface plasmon resonance sensing with adjustable sensitivity based on a flexible liquid core coupling unit.TALANTA,184,468-474.
MLA	Xu, Jiying,et al."Surface plasmon resonance sensing with adjustable sensitivity based on a flexible liquid core coupling unit".TALANTA 184(2018):468-474.