Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides

doi:10.3390/molecules23040760

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	Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides
	Nie, Yanzhao 1; Zhi, Xinmei 1; Du, Haifeng 2; Yang, Jing 1
刊名	MOLECULES
	2018-04-01
卷号	23 期号:4
关键词	Lewis Pair Polymerization Polymerization Catalysis Polymer Synthesis Polypeptides Ring-opening Polymerization
ISSN号	1420-3049
DOI	10.3390/molecules23040760
英文摘要	Despite notable progress, the fabrication of well-defined polypeptides via controlled ring-opening polymerization (ROP) of alpha-amino acid N-carboxyanhydrides (NCAs) using convenient catalysts under mild conditions in a relatively short polymerization time is still challenging. Herein, an easily obtained catalyst system composed of zinc acetate and aniline was explored to mediate the fast ROP of gamma-benzyl-L-glutamate-N-carboxyanhydride (BLG-NCA) monomer, to produce poly(gamma-benzyl-L-glutamates) (PBLGs) with controllable molecular weights and narrow dispersity. Considering the excellent cooperative action of zinc acetate and a broad scope of aniline derivatives with different functional groups to control ROP of BLG-NCA, this method may offer a useful platform enabling the rapid generation of end-functionalized PBLG and block copolymers for numerous biomedical applications.
语种	英语
出版者	MDPI
WOS记录号	WOS:000434717300052
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/42587]
专题	中国科学院化学研究所
通讯作者	Du, Haifeng; Yang, Jing
作者单位	1.Beijing Univ Chem Technol, Coll Life Sci & Technol, State Key Lab Chem Resource Engn, Beijing Key Lab Bioproc, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Nie, Yanzhao,Zhi, Xinmei,Du, Haifeng,et al. Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides[J]. MOLECULES,2018,23(4).
APA	Nie, Yanzhao,Zhi, Xinmei,Du, Haifeng,&Yang, Jing.(2018).Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides.MOLECULES,23(4).
MLA	Nie, Yanzhao,et al."Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides".MOLECULES 23.4(2018).