C-70-Carboxyfullerenes as Efficient Antioxidants to Protect Cells against Oxidative-Induced Stress

doi:10.1021/am4033372

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	C-70-Carboxyfullerenes as Efficient Antioxidants to Protect Cells against Oxidative-Induced Stress
	Liu, Qiaoling; Zhang, Xuejie; Zhang, Xinyue; Zhang, Guoqiang; Zheng, Junpeng; Guan, Mirong; Fang, Xiaohong; Wang, Chunru; Shu, Chunying
刊名	ACS APPLIED MATERIALS & INTERFACES
	2013-11-13
卷号	5 期号:21 页码:11101-11107
关键词	Carboxyfullerene Oxidative Stress Cell Viability Intracellular Location C2c12 Cell
ISSN号	1944-8244
DOI	10.1021/am4033372
英文摘要	Oxidative stress induced by excessive production of reactive oxygen species (ROS) has been implicated in the etiology of many human diseases. Acquiring a highly efficient antioxidant with good biocompatibility is of significance in eliminating the deleterious effect induced by the oxidative stress. Herein, we address our efforts on investigating the cytoprotective effect of carboxyfullerenes on H2O2-injured cells. Meanwhile, the uptake and intracellular location of carboxyfullerenes were studied. The results show, that C-70-carboxyfullerenes (dimalonic acid C-70 fullerene (DF70) and trimalonic acid C-70 fullerene (TF70)) exhibit an obviously protective effect against oxidative stress on C2C12 cells at concentrations as low as 2.5 mu mol L-1 whereas C-60-carboxyfullerenes (dimalonic acid C-60 fullerene (DF60) and quadrimalonic acid C60 fullerene (QF(60))) show a protective effect at relatively higher concentration (40 mu mol L-1)The molecular structure of carboxyfullerenes and the physiological state of cells play an important role in the different cytoprotective capability. Further study reveals that DF70 and TF70 could enter into cells and mainly localize into the lysosome, which possibly involves the protective mechanism by stabilizing lysosome. The use of a significantly low concentration of C-70-carboxyfullerene as the antioxidative agent will benefit the therapeutic approaches aiming at alleviating ROS-induced injuries such as muscle disorder and arthritis.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000327103500091
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/42050]
专题	中国科学院化学研究所
通讯作者	Shu, Chunying
作者单位	Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Liu, Qiaoling,Zhang, Xuejie,Zhang, Xinyue,et al. C-70-Carboxyfullerenes as Efficient Antioxidants to Protect Cells against Oxidative-Induced Stress[J]. ACS APPLIED MATERIALS & INTERFACES,2013,5(21):11101-11107.
APA	Liu, Qiaoling.,Zhang, Xuejie.,Zhang, Xinyue.,Zhang, Guoqiang.,Zheng, Junpeng.,...&Shu, Chunying.(2013).C-70-Carboxyfullerenes as Efficient Antioxidants to Protect Cells against Oxidative-Induced Stress.ACS APPLIED MATERIALS & INTERFACES,5(21),11101-11107.
MLA	Liu, Qiaoling,et al."C-70-Carboxyfullerenes as Efficient Antioxidants to Protect Cells against Oxidative-Induced Stress".ACS APPLIED MATERIALS & INTERFACES 5.21(2013):11101-11107.