Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii

	Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii
	Cao, Tuan-Wu ; Geng, Chang-An ; Ma, Yun-Bao ; He, Kang ; Wang, Hong-Ling ; Zhou, Ning-Jia ; Zhang, Xue-Mei ; Tao, Yan-Duo ; Chen, Ji-Jun ; Chen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Peoples R China.
刊名	PLANTA MEDICA ; Cao, TW; Geng, CA; Ma, YB; He, K; Wang, HL; Zhou, NJ; Zhang, XM; Tao, YD; Chen, JJ.Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii,PLANTA MEDICA,2013,79(8):697-700
	2013-05-01
英文摘要	Two new xanthones, 8-O-beta-D-glucopyranosyl-1-hydroxy-2,3,5-trimethoxyxanthone (1) and 8-O-[beta-D-xylopyranosyl-(1 -> 6)-beta-D-glucopyranosyl]-1-hydroxy-2,3,5-trimethoxyxanthone (2), along with eighteen known xanthones (3-20) were isolated from Swertia mussotii. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, IR, [alpha](D)). All compounds were evaluated for their anti-hepatitis B virus activities on HepG 2.2.15 cells line in vitro, and compounds 3-10 exhibited significant activity inhibiting hepatitis B virus DNA replication with IC50 values from 0.01 mM to 0.13 mM. Compounds 3-5 showed remarkable activity with IC50 values of 0.77, >0.98, and 0.21 mM for HBsAg, and <0.62, 0.35, and 0.04 mM for HBeAg, respectively. Meanwhile, the effects of different substitutions on the anti-hepatitis B virus activity of xanthones from S. mussotii were discussed.; Two new xanthones, 8-O-beta-D-glucopyranosyl-1-hydroxy-2,3,5-trimethoxyxanthone (1) and 8-O-[beta-D-xylopyranosyl-(1 -> 6)-beta-D-glucopyranosyl]-1-hydroxy-2,3,5-trimethoxyxanthone (2), along with eighteen known xanthones (3-20) were isolated from Swertia mussotii. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, IR, [alpha](D)). All compounds were evaluated for their anti-hepatitis B virus activities on HepG 2.2.15 cells line in vitro, and compounds 3-10 exhibited significant activity inhibiting hepatitis B virus DNA replication with IC50 values from 0.01 mM to 0.13 mM. Compounds 3-5 showed remarkable activity with IC50 values of 0.77, >0.98, and 0.21 mM for HBsAg, and <0.62, 0.35, and 0.04 mM for HBeAg, respectively. Meanwhile, the effects of different substitutions on the anti-hepatitis B virus activity of xanthones from S. mussotii were discussed.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/3945]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Cao, Tuan-Wu,Geng, Chang-An,Ma, Yun-Bao,et al. Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii[J]. PLANTA MEDICA, Cao, TW; Geng, CA; Ma, YB; He, K; Wang, HL; Zhou, NJ; Zhang, XM; Tao, YD; Chen, JJ.Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii,PLANTA MEDICA,2013,79(8):697-700,2013.
APA	Cao, Tuan-Wu.,Geng, Chang-An.,Ma, Yun-Bao.,He, Kang.,Wang, Hong-Ling.,...&Chen, JJ .(2013).Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii.PLANTA MEDICA.
MLA	Cao, Tuan-Wu,et al."Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii".PLANTA MEDICA (2013).