Insights into Morphological Transition of Pluronic P123 Micelles as a Function of Gallate

doi:10.1016/j.colsurfa.2019.04.005

	Insights into Morphological Transition of Pluronic P123 Micelles as a Function of Gallate
	Luo, Haiyan 1,2; Jiang, Kun 1,2; Liang, Xiangfeng 3; Hua, Chao 1; Li, Yingbo 1; Liu, Huizhou 1
刊名	COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
	2019-07-05
卷号	572 页码:221-229
关键词	Pluronic Morphological transition Gallate Interaction Molecular simulation
ISSN号	0927-7757
DOI	10.1016/j.colsurfa.2019.04.005
英文摘要	Pluronics have emerged as a potential agent for solubilizing a variety of lipophilic bioactive molecules, but how these solubilizates affect the morphology of Pluronic micelles still remains poorly understood. In this work, the morphological transition of Pluronic P123 micelles induced by three gallate homologs with different alkyl chain length, namely methyl gallate (MG), propyl gallate (PG) and octyl gallate (OG) has been comprehensively investigated by combination of dynamic light scattering (DLS), cryogenic transmission electron microscopy (Cryo-TEM), H-1 NMR and atom-scale molecular dynamic simulations. It is found that addition of the three gallate significantly increases the micellar sizes and polydispersities. Cryo-TEM measurements reveal that spherical P123 micelles form micellar clusters in the presence of PG and short rod micelles with OG, while MG do not change the micellar morphology. Qualitative interactions between various gallate and P123 micelle are determined by NMR experiments. It is demonstrated that the different locations of various gallate in the micelles are governed by the balance of hydrophobic interaction and hydrogen bonding, which consequently leads to the varying micellar morphologies. The experimental results are further confirmed by dynamic molecular stimulation. We also show that the intensity of Pluronic-gallate interaction increases with the hydrophobicity of the gallate, indicating that hydrophobic interaction is more important on the morphological transition. Finally, the mechanism of morphological transition induced by various gallate are discussed and proposed, where the nature of formation of micellar cluster induced by PG is particularly emphasized.
资助项目	National Natural Science Foundation of China[21506221] ; National Natural Science Foundation of China[21676283]
WOS关键词	PEO BLOCK-COPOLYMERS ; ANGLE NEUTRON-SCATTERING ; SPHERE-TO-ROD ; AGGREGATION BEHAVIOR ; TRIBLOCK COPOLYMERS ; CRYO-TEM ; DRUG ; SOLUBILIZATION ; TEMPERATURE ; MICELLIZATION
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000466612900024
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/29789]
专题	中国科学院过程工程研究所
通讯作者	Li, Yingbo; Liu, Huizhou
作者单位	1.Chinese Acad Sci, CAS Key Lab Green Proc & Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266061, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Luo, Haiyan,Jiang, Kun,Liang, Xiangfeng,et al. Insights into Morphological Transition of Pluronic P123 Micelles as a Function of Gallate[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2019,572:221-229.
APA	Luo, Haiyan,Jiang, Kun,Liang, Xiangfeng,Hua, Chao,Li, Yingbo,&Liu, Huizhou.(2019).Insights into Morphological Transition of Pluronic P123 Micelles as a Function of Gallate.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,572,221-229.
MLA	Luo, Haiyan,et al."Insights into Morphological Transition of Pluronic P123 Micelles as a Function of Gallate".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 572(2019):221-229.