In vitro and in vivo investigation of the novel Dex-bHb as oxygen carriers

doi:10.1080/21691401.2018.1489273

	In vitro and in vivo investigation of the novel Dex-bHb as oxygen carriers
	Zhang, Jun 1; Wang, Ying 1; Zhang, Shan 1; You, Guo-Xing 1; Li, Peng-Long 1; Wang, Quan 1; Yu, Wei-Li 2; Hu, Tao 2; Zhou, Hong 1; Zhao, Lian 1
刊名	ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
	2018
卷号	46 页码:S133-S137
关键词	HBOCs Dex-bHb blood compatibility organ protection
ISSN号	2169-1401
DOI	10.1080/21691401.2018.1489273
英文摘要	The development of hemoglobin-based oxygen carriers (HBOCs) is a persistent and urgent need in biomedicine. As a potential HBOCs, Dextran-hemoglobin (Dex-bHb) has been developed over the past years. The novel Dex-bHb, whose thiol group of Cys-93(beta) was reversibly protected, was produced and the characteristics were evaluated in our previous study. Herein, blood compatibility was characterized in terms of the red blood cell aggregation and hemolysis rate in vitro, and Dex-bHb showed no obvious effects. After intravenous administration of Dex-bHb to golden Syrian hamsters with hemorrhages shock, it showed mean arterial pressure recovery, blood flow increase and the organ protection from serious hemorrhage injury. Consequently, Dex-bHb is hopeful to be a safe and available blood substitute.
资助项目	National Natural Science Foundation of China[81700181] ; National Natural Science Foundation of China[81600148]
WOS关键词	BLOOD SUBSTITUTES ; HEMOGLOBIN ; DEXTRAN ; RESUSCITATION ; BINDING
WOS研究方向	Biotechnology & Applied Microbiology ; Engineering ; Materials Science
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000460141900013
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/28632]
专题	中国科学院过程工程研究所
通讯作者	Hu, Tao; Zhou, Hong; Zhao, Lian
作者单位	1.Acad Mil Med Sci, Inst Hlth Serv & Transfus Med, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jun,Wang, Ying,Zhang, Shan,et al. In vitro and in vivo investigation of the novel Dex-bHb as oxygen carriers[J]. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,2018,46:S133-S137.
APA	Zhang, Jun.,Wang, Ying.,Zhang, Shan.,You, Guo-Xing.,Li, Peng-Long.,...&Zhao, Lian.(2018).In vitro and in vivo investigation of the novel Dex-bHb as oxygen carriers.ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,46,S133-S137.
MLA	Zhang, Jun,et al."In vitro and in vivo investigation of the novel Dex-bHb as oxygen carriers".ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 46(2018):S133-S137.