Magnetic Nanoclusters Armed with Responsive PD-1 Antibody Synergistically Improved Adoptive T-Cell Therapy for Solid Tumors | |
Nie, Weidong1; Wei, Wei2; Zuo, Liping1; Lv, Chengliang1; Zhang, Fan1; Lu, Gui-Hong1; Li, Feng1; Wu, Guanghao1; Huang, Li-Li1; Xi, Xiaobo2 | |
刊名 | ACS NANO |
2019-02-01 | |
卷号 | 13期号:2页码:1469-1478 |
关键词 | Adoptive T-cell Therapy Intratumoral Microenvironment Magnetic Nanoclusters Ph Sensitive Solid Tumor |
ISSN号 | 1936-0851 |
DOI | 10.1021/acsnano.8b07141 |
英文摘要 | Although adoptive T-cell therapy has been successful in hematological malignancy treatment, its application in solid tumors remains a great challenge. Here, using a pH-sensitive benzoic-imine bond and inverse electron-demand Diels-Alder cycloaddition, we prepared magnetic nanoclusters (NCs) armed with responsive PD-1 antibody (aP), which could then bind onto effector T cells due to their PD-1 expression. After adoptive transfer, the magnetization and superparamagnetism of NCs enabled us to magnetically recruit effector T cells and aP simultaneously to tumor sites with MRI guidance. Owing to the acidic intratumoral microenvironment, the benzoic-imine bond then hydrolyzed, leading to the release of aP. The therapeutic effects of adoptive T cells and free aP could thus be spatiotemporally coupled. As a result, we achieved inhibition of tumor growth with few side effects, demonstrating the great promise of such a chemical approach for safe and high-performance adoptive T-cell therapy against solid tumors. |
资助项目 | National Natural Science Foundation of China[81571813] ; National Natural Science Foundation of China[21874011] ; National Natural Science Foundation of China[21372028] ; National Natural Science Foundation of China[21422502] ; National Natural Science Foundation of China[81302704] ; National Natural Science Foundation of China[21622608] ; National Key R&D Program of China[2017YFA0207900] ; Beijing Talents Fund[2015000021223ZK20] |
WOS关键词 | Regulatory t ; Blockade ; Immunotherapy ; Trafficking ; Tolerance ; Immunity |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
语种 | 英语 |
出版者 | AMER CHEMICAL SOC |
WOS记录号 | WOS:000460199400048 |
资助机构 | National Natural Science Foundation of China ; National Key R&D Program of China ; Beijing Talents Fund |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/28347] |
专题 | 中国科学院过程工程研究所 |
通讯作者 | Xie, Hai-Yan |
作者单位 | 1.Beijing Inst Technol, Sch Life Sci, 5 South St, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North Second St, Beijing 100190, Peoples R China |
推荐引用方式 GB/T 7714 | Nie, Weidong,Wei, Wei,Zuo, Liping,et al. Magnetic Nanoclusters Armed with Responsive PD-1 Antibody Synergistically Improved Adoptive T-Cell Therapy for Solid Tumors[J]. ACS NANO,2019,13(2):1469-1478. |
APA | Nie, Weidong.,Wei, Wei.,Zuo, Liping.,Lv, Chengliang.,Zhang, Fan.,...&Xie, Hai-Yan.(2019).Magnetic Nanoclusters Armed with Responsive PD-1 Antibody Synergistically Improved Adoptive T-Cell Therapy for Solid Tumors.ACS NANO,13(2),1469-1478. |
MLA | Nie, Weidong,et al."Magnetic Nanoclusters Armed with Responsive PD-1 Antibody Synergistically Improved Adoptive T-Cell Therapy for Solid Tumors".ACS NANO 13.2(2019):1469-1478. |
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