Fabrication of Multilayered Molecularly Imprinted Membrane for Selective Recognition and Separation of Artemisinin

doi:10.1021/acssuschemeng.8b04908

	Fabrication of Multilayered Molecularly Imprinted Membrane for Selective Recognition and Separation of Artemisinin
	Zhang, YQ; Tan, X; Liu, X; Li, CS; Zeng, SJ; Wang, H; Zhang, SJ; Zhang, Yongqiang; Tan, Xin; Liu, Xiao
刊名	ACS SUSTAINABLE CHEMISTRY & ENGINEERING
	2019
卷号	7 期号:3 页码:3127
关键词	Artemisinin ANNUA L. Molecularly imprinted membrane ASSISTED EXTRACTION Chitosan PURIFICATION Permselectivity SILICA COPOLYMERS PARTICLES SOLVENT ACID ATRP
ISSN号	2168-0485
DOI	10.1021/acssuschemeng.8b04908
文献子类	Article
英文摘要	Molecularly imprinted membranes with multifunctional layers for artemisinin separation and purification were fabricated on porous chitosan membranes. The molecularly imprinted layer was fabricated through an in situ activator generated by electron transfer atom transfer radical polymerization method by using artemisinin as the templet molecule. Properties of the prepared materials were characterized by SEM, IR, XPS, EDS, AFM, etc. Adsorption ability and dynamics, permeation capacity, and reusability have been investigated. Results indicate that this kind of molecularly imprinted membrane possesses desirable adsorption ability for artemisinin (18.89 mg/g) and permselectivity factors (beta) as high as 2.15 and 2.03 toward artemether and artesunate, respectively. Mechanism of selective adsorption and permeation was unveiled by molecular simulation, which indicates that the tailor-made recognition sites on the membrane possess higher interaction force toward artemisinin than artemether or artesunate, resulting in artemisinin adsorption by the membrane and separation of this drug from its analogues. The method developed here provides an environmental friendly and sustainable technology for separation and purification of natural products.
WOS记录号	WOS:000458086100031
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/28341]
专题	中国科学院过程工程研究所
推荐引用方式 GB/T 7714	Zhang, YQ,Tan, X,Liu, X,et al. Fabrication of Multilayered Molecularly Imprinted Membrane for Selective Recognition and Separation of Artemisinin[J]. ACS SUSTAINABLE CHEMISTRY & ENGINEERING,2019,7(3):3127, 3137.
APA	Zhang, YQ.,Tan, X.,Liu, X.,Li, CS.,Zeng, SJ.,...&Zhang, Suojiang.(2019).Fabrication of Multilayered Molecularly Imprinted Membrane for Selective Recognition and Separation of Artemisinin.ACS SUSTAINABLE CHEMISTRY & ENGINEERING,7(3),3127.
MLA	Zhang, YQ,et al."Fabrication of Multilayered Molecularly Imprinted Membrane for Selective Recognition and Separation of Artemisinin".ACS SUSTAINABLE CHEMISTRY & ENGINEERING 7.3(2019):3127.