Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics

doi:10.1039/c9sc00324j

	Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics
	Lu, Guihong 1; Lv, Chengliang 1; Bao, Weier 2; Li, Feng 1; Zhang, Fan 1; Zhang, Lijun 2; Wang, Shuang 2; Gao, Xiaoyong 2; Zhao, Dongxu 1; Wei, Wei 2
刊名	CHEMICAL SCIENCE
	2019-05-14
卷号	10 期号:18 页码:4847-4853
ISSN号	2041-6520
DOI	10.1039/c9sc00324j
英文摘要	Although the antimonene (AM) nanomaterial is recently emerging as a new photothermal therapy (PTT) agent, its rapid degradation in physiological medium immensely limits its direct utilization. To this end, we herein engineered AM by the cooperation of dimension optimization, size control, and cell membrane (CM) camouflage. Compared with traditional AM nanosheets, the resulting AM nanoparticles (similar to 55 nm) cloaked with the CM (denoted as CmNPs) exhibited significantly improved stability and increased photothermal efficacy as well as superior tumor targeting capacity. After intravenous injection, the CmNPs enabled satisfactory photoacoustic/ photothermal multimodal imaging at tumor sites. Meanwhile, the PTT together with the newly explored function of photodynamic therapy (PDT) achieved a potent combination therapy with few side effects. The maximized theranostic performance thus strongly recommends CmNPs as a safe and highly reliable modality for anticancer therapy.
资助项目	National Natural Science Foundation of China[81571813] ; National Natural Science Foundation of China[21874011] ; National Natural Science Foundation of China[21622608] ; National Science and Technology Major Project[2018ZX 10301405-001] ; National Key R&D Program of China[2017YFA0207900]
WOS关键词	CLEARANCE ABC PHENOMENON ; OXIDE NANOPARTICLES ; BLACK PHOSPHORUS ; THERAPY ; SIZE
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000468818700011
资助机构	National Natural Science Foundation of China ; National Science and Technology Major Project ; National Key R&D Program of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/28203]
专题	中国科学院过程工程研究所
通讯作者	Wei, Wei; Xie, Hai-yan
作者单位	1.Beijing Inst Technol, Sch Life Sci, 5 South Zhong Guan Cun St, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Lu, Guihong,Lv, Chengliang,Bao, Weier,et al. Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics[J]. CHEMICAL SCIENCE,2019,10(18):4847-4853.
APA	Lu, Guihong.,Lv, Chengliang.,Bao, Weier.,Li, Feng.,Zhang, Fan.,...&Xie, Hai-yan.(2019).Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics.CHEMICAL SCIENCE,10(18),4847-4853.
MLA	Lu, Guihong,et al."Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics".CHEMICAL SCIENCE 10.18(2019):4847-4853.