Improved matrix pooling

doi:10.1177/0962280217719914

CORC > 数学与系统科学研究院 > 中国科学院数学与系统科学研究院 > 系统科学研究所

	Improved matrix pooling
	Xiong, Wenjun 1,2; Ding, Juan 1,3; He, Yuanzhen 4; Li, Qizhai2
刊名	STATISTICAL METHODS IN MEDICAL RESEARCH
	2019
卷号	28 期号:1 页码:211-222
关键词	Matrix pooling efficiency group testing sensitivity specificity
ISSN号	0962-2802
DOI	10.1177/0962280217719914
英文摘要	Pooled testing is useful to identify positive specimens for large-scale screening. Matrix pooling is one of the commonly used algorithms. In this work, we investigate the properties of matrix pooling and reveal that the efficiency of matrix pooling is related with the magnitude of overlapping among groups. Based on this property, we develop a new design to further improve the efficiency while taking into account of testing error. The efficiency, pooling sensitivity and specificity of this algorithm are explicitly derived and verified through plasmode simulation of detecting acute human immunodeficiency virus among patients who were suspected to have malaria in rural Ugandan. We show that the new design outperforms matrix pooling in efficiency while retain the pooling sensitivity and specificity.
资助项目	National Natural Science Foundation of China[11526061] ; National Natural Science Foundation of China[11501134] ; National Natural Science Foundation of China[11371353] ; Guangxi Natural Science Foundation[2015GXNSFBA139016] ; key project of Guangxi Normal University[2014ZD002] ; Program on the High Level Innovation Team and Outstanding Scholars in Universities of Guangxi Province ; Special National Key Research and Development Plan[2016YFD0400206] ; Breakthrough Projects of Strategic Priority Program of the Chinese Academy of Sciences[XDB13040600]
WOS研究方向	Health Care Sciences & Services ; Mathematical & Computational Biology ; Medical Informatics ; Mathematics
语种	英语
出版者	SAGE PUBLICATIONS LTD
WOS记录号	WOS:000454598800014
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/32063]
专题	系统科学研究所
通讯作者	Xiong, Wenjun
作者单位	1.Guangxi Normal Univ, Sch Math & Stat, Guilin, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China 3.Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA 4.Beijing Normal Univ, Sch Math Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Xiong, Wenjun,Ding, Juan,He, Yuanzhen,et al. Improved matrix pooling[J]. STATISTICAL METHODS IN MEDICAL RESEARCH,2019,28(1):211-222.
APA	Xiong, Wenjun,Ding, Juan,He, Yuanzhen,&Li, Qizhai.(2019).Improved matrix pooling.STATISTICAL METHODS IN MEDICAL RESEARCH,28(1),211-222.
MLA	Xiong, Wenjun,et al."Improved matrix pooling".STATISTICAL METHODS IN MEDICAL RESEARCH 28.1(2019):211-222.