The metabolism distribution and effect of dinotefuran in Chinese lizards (Eremias argus)

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 中国科学院环境生物技术重点实验室

	The metabolism distribution and effect of dinotefuran in Chinese lizards (Eremias argus)
	Xu, Peng; Wang, Yinghuan; Han, Yongtao; Xie, Yun; Li, Wei
刊名	CHEMOSPHERE
	2018-11-01
卷号	211 页码:591-599
关键词	Eremias argus Dinotefuran Metabolism Distribution
ISSN号	0045-6535
文献子类	Article
英文摘要	The Chinese lizards (Eremias argus) were used to evaluate the metabolism, distribution and effect of dinotefuran following oral exposed. The HPLC equipped with Q Exactive focus was used for metabolite identification and concentration analysis. After single oral administration, the time-concentration curves of dinotefuran and its metabolites were tissue-dependent. The liver and kidney were the major metabolic organs. Percutaneous and urinary excretions were the main ways for lizards to eliminate dinotefuran, and the urine output was the limiting factor. Nitro-reduction was an important process of the metabolism of dinotefuran that was dominated by aldehyde oxidase, and P450 enzymes were involved. The CYP3A4 and CYP2C19 played a crucial role in the other metabolic pathways of dinotefuran. The mRNA expressions of GST family were severely inhibited in liver, which showed dinotefuran might pose a risk of damaging the oxidative stress system in liver. Prolonged residuals of dinotefuran and its demethylation metabolite might enhance the risk of dinotefuran to brain. The results enrich and supplement the knowledge of the environmental fate of dinotefuran in reptiles. (C) 2018 Elsevier Ltd. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/41301]
专题	生态环境研究中心_中国科学院环境生物技术重点实验室
推荐引用方式 GB/T 7714	Xu, Peng,Wang, Yinghuan,Han, Yongtao,et al. The metabolism distribution and effect of dinotefuran in Chinese lizards (Eremias argus)[J]. CHEMOSPHERE,2018,211:591-599.
APA	Xu, Peng,Wang, Yinghuan,Han, Yongtao,Xie, Yun,&Li, Wei.(2018).The metabolism distribution and effect of dinotefuran in Chinese lizards (Eremias argus).CHEMOSPHERE,211,591-599.
MLA	Xu, Peng,et al."The metabolism distribution and effect of dinotefuran in Chinese lizards (Eremias argus)".CHEMOSPHERE 211(2018):591-599.