PFOA and PFOS Disrupt the Generation of Human Pancreatic Progenitor Cells

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	PFOA and PFOS Disrupt the Generation of Human Pancreatic Progenitor Cells
	Yin, Nuoya; Liu, Shuyu; Faiola, Francesco
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
	2018-05-01
卷号	5 期号:5 页码:237-242
ISSN号	2328-8930
文献子类	Article
英文摘要	The two most infamous perfluoroalkyl acids, PFOA and PFOS, are persistent, widespread, bioaccumulative, and associated with many health issues. However, knowledge about their potential toxicity to the developing pancreas or their association with metabolic diseases, such as diabetes, in humans is limited. In this study, we investigated the effects of PFOA and PFOS on the in vitro generation of pancreatic progenitor cells from human embryonic stem cells, a process that mimics in vivo organogenesis. We demonstrated for the first time that these two pollutants significantly affect the early stages of human pancreatic progenitor cell specification, even at very low environmentally and human-relevant doses. Thus, our findings further emphasize the substantial health risks associated with prenatal exposure to PFOA and PFOS.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/41011]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Yin, Nuoya,Liu, Shuyu,Faiola, Francesco. PFOA and PFOS Disrupt the Generation of Human Pancreatic Progenitor Cells[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS,2018,5(5):237-242.
APA	Yin, Nuoya,Liu, Shuyu,&Faiola, Francesco.(2018).PFOA and PFOS Disrupt the Generation of Human Pancreatic Progenitor Cells.ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS,5(5),237-242.
MLA	Yin, Nuoya,et al."PFOA and PFOS Disrupt the Generation of Human Pancreatic Progenitor Cells".ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS 5.5(2018):237-242.