Subdivisions of the posteromedial cortex in disorders of consciousness

doi:10.1016/j.nicl.2018.07.025

	Subdivisions of the posteromedial cortex in disorders of consciousness
	Cui, Yue1,2,3 ; Song, Ming1,2,3 ; Lipnicki, Darren M.4; Yang, Yi 5; Ye, Chuyang1,2,3 ; Fan, Lingzhong1,2,3 ; Sui, Jing1,2,3,6,9 ; Jiang, Tianzi1,2,3,7,8,9 ; He, Jianghong 5
刊名	NEUROIMAGE-CLINICAL
	2018
卷号	20 页码:260-266
关键词	Default mode network Diffusion tensor imaging Disorders of consciousness Parcellation Parietal cortex Persistent vegetative state
ISSN号	2213-1582
DOI	10.1016/j.nicl.2018.07.025
通讯作者	Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn) ; He, Jianghong(he_jianghong@sina.cn)
英文摘要	Evidence suggests that disruptions of the posteromedial cortex (PMC) and posteromedial corticothalamic connectivity contribute to disorders of consciousness (DOCs). While most previous studies treated the PMC as a whole, this structure is functionally heterogeneous. The present study investigated whether particular subdivisions of the PMC are specifically associated with DOCs. Participants were DOC patients, 21 vegetative state/unresponsive wakefulness syndrome (VS/UWS), 12 minimally conscious state (MCS), and 29 healthy controls. Individual PMC and thalamus were divided into distinct subdivisions by their fiber tractograpy to each other and default mode regions, and white matter integrity and brain activity between/within subdivisions were assessed. The thalamus was represented mainly in the dorsal and posterior portions of the PMC, and the white matter tracts connecting these subdivisions to the thalamus had less integrity in VS/UWS patients than in MCS patients and healthy controls. In addition, these tracts had less integrity in DOC patients who did not recover after 12 months than in patients who did. The structural substrates were validated by resting state fMRI finding impaired functional activity within these PMC subdivisions. This study is the first to show that tracts from dorsal and posterior subdivisions of the PMC to the thalamus contribute to DOCs.
资助项目	Natural Science Foundation of China[31771076] ; Natural Science Foundation of China[81771128] ; Natural Science Foundation of China[91432302] ; Natural Science Foundation of China[31620103905] ; Science Frontier Program of the Chinese Academy of Sciences[QYZDJ-SSW-SMC019] ; National Key R&D Program of China[2017YFA0105203] ; Beijing Municipal Science & Technology Commission[Z141107002514111] ; Beijing Municipal Science & Technology Commission[Z161100000216152] ; Beijing Municipal Science & Technology Commission[Z161100000216139] ; Guangdong Pearl River Talents Plan[2016ZT06S220]
WOS关键词	DEFAULT MODE NETWORK ; CONNECTIVITY-BASED PARCELLATION ; TRAUMATIC BRAIN-INJURY ; FUNCTIONAL CONNECTIVITY ; VEGETATIVE STATE ; RESTING-STATE ; STRUCTURAL CONNECTIVITY ; CINGULATE CORTEX ; AXONAL INJURY ; RECOVERY
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000450799000029
资助机构	Natural Science Foundation of China ; Science Frontier Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; Beijing Municipal Science & Technology Commission ; Guangdong Pearl River Talents Plan
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/25703]
专题	中国科学院自动化研究所
通讯作者	Jiang, Tianzi; He, Jianghong
作者单位	1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Univ New South Wales, Sch Psychiat, CHeBA Ctr Healthy Brain Ageing, Randwick, NSW 2031, Australia 5.PLA Army Gen Hosp, Dept Neurosurg, Beijing 100700, Peoples R China 6.Mind Res Network & Lovelace Biomed & Environm Res, Albuquerque, NM 87106 USA 7.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Sichuan, Peoples R China 8.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia 9.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Cui, Yue,Song, Ming,Lipnicki, Darren M.,et al. Subdivisions of the posteromedial cortex in disorders of consciousness[J]. NEUROIMAGE-CLINICAL,2018,20:260-266.
APA	Cui, Yue.,Song, Ming.,Lipnicki, Darren M..,Yang, Yi.,Ye, Chuyang.,...&He, Jianghong.(2018).Subdivisions of the posteromedial cortex in disorders of consciousness.NEUROIMAGE-CLINICAL,20,260-266.
MLA	Cui, Yue,et al."Subdivisions of the posteromedial cortex in disorders of consciousness".NEUROIMAGE-CLINICAL 20(2018):260-266.