Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer

doi:10.1039/c8nr08109c

	Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer
	Yan, Hao 1,2; Shang, Wenting3 ; Sun, Xiaodan 1; Zhao, Lingyun 1; Wang, Xiumei 1; Zhang, Shuixing 4; Xu, Nan 1; Xu, Wanhai 5; Tian, Jie3 ; Kang, Feiyu 1,2
刊名	NANOSCALE
	2019-01-14
卷号	11 期号:2 页码:706-716
ISSN号	2040-3364
DOI	10.1039/c8nr08109c
通讯作者	Xu, Wanhai(xuwanhai@163.com) ; Tian, Jie(jie.tian@ia.ac.cn) ; Kang, Feiyu(fykang@mail.tsinghua.edu.cn)
英文摘要	Nano-photothermal therapy (NPTT) has attracted increasing interest recently due to its high efficiency, excellent selectivity and non-ionizing radiation damage. Despite a tremendous amount of exciting pre-clinical results reported in the past few years, however, the further clinic application of NPTT is still difficult. To combine NPTT with clinical surgery more closely, novel multifunctional optical-magnetic nanosystems have been synthesized and applied for preoperative NPTT to assist in the follow-up surgery, termed "neoadjuvant NPTT". Remarkably, nanoparticles are mainly aggregated in the cytoplasm of tumor cells in vitro and largely accumulated in the tumor in vivo 24 h after injection. Under the guidance of tri-modality imaging, preoperative NPTT could shrink the tumor in a short time and make the boundary between the tumor and surrounding normal tissues clearer, which is conducive to subsequent surgery resection. Furthermore, the 50% survival rate is up to 50 days compared with 35 days for standard surgery, 31 days for PTT alone and 24 days for non-surgery groups. Therefore, NPTT can effectively assist in surgery used before operation. This study provides a new idea for the clinical transformation of NPTT in the future.
资助项目	National Key Research and Development Program of China[2016YFB0700800] ; Intergovernmental Cooperation in Science and Technology[2016YFE0125300] ; NSFC[81172182] ; NSFC[81671829] ; fund of Key Laboratory of Advanced Materials of Ministry of Education[2017AML12]
WOS关键词	NANOPARTICLES ; CHEMOTHERAPY ; NANOSHELLS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000455001600035
资助机构	National Key Research and Development Program of China ; Intergovernmental Cooperation in Science and Technology ; NSFC ; fund of Key Laboratory of Advanced Materials of Ministry of Education
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/25639]
专题	中国科学院自动化研究所
通讯作者	Xu, Wanhai; Tian, Jie; Kang, Feiyu
作者单位	1.Tsinghua Univ, Sch Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Beijing 100084, Peoples R China 2.Tsinghua Univ, Grad Sch Shenzhen, Engn Lab Functionalized Carbon Mat, Shenzhen 518055, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Jinan Univ, Affiliated Hosp 1, Dept Radiol, Guangzhou, Guangdong, Peoples R China 5.Harbin Med Univ, Hosp 4, Urol Surg Dept, Harbin 150001, Heilongjiang, Peoples R China
推荐引用方式 GB/T 7714	Yan, Hao,Shang, Wenting,Sun, Xiaodan,et al. Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer[J]. NANOSCALE,2019,11(2):706-716.
APA	Yan, Hao.,Shang, Wenting.,Sun, Xiaodan.,Zhao, Lingyun.,Wang, Xiumei.,...&Kang, Feiyu.(2019).Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer.NANOSCALE,11(2),706-716.
MLA	Yan, Hao,et al."Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer".NANOSCALE 11.2(2019):706-716.