Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head

doi:10.1155/2019/8914569

	Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head
	Wang, Yi1,2 ; Ma, Xibo2,3 ; Chai, Wei 1; Tian, Jie2,3
刊名	STEM CELLS INTERNATIONAL
	2019
页码	13
ISSN号	1687-966X
DOI	10.1155/2019/8914569
通讯作者	Chai, Wei(chaiwei301@163.com) ; Tian, Jie(tian@ieee.org)
英文摘要	The last couple of decades have seen brilliant progress in stem cell therapies, including native, genetically modified, and engineered stem cells, for osteonecrosis of the femoral head (ONFH). In vitro studies evaluate the effect of endogenous or exogenous factor or gene regulation on osteogenic phenotype maintenance and/or differentiation towards osteogenic lineage. The preclinical and clinical outcomes accelerate the clinical translation. Bone marrow mesenchymal stem cells and adipose-derived stem cells have demonstrated better effects in the treatment of femoral head necrosis. Various materials have been used widely in the ONFH treatment in both preclinical and clinical trials. In a word, in vivo and multiscale efforts are expected to overcome obstacles in the approaches for treating ONFH and provide clinical relevance and commercial strategies in the future. Therefore, we will discuss the above aspects in this paper and present our opinions.
资助项目	National Key Research Program of China[2016YFA0100900] ; National Key Research Program of China[2016YFA0100902] ; National Natural Science Foundation of China[81772320] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[815270805] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81471739] ; National Natural Science Foundation of China[81472594] ; National Natural Science Foundation of China[81770781] ; Key Research Program of the Chinese Academy of Sciences[KGZD-EW-T03] ; Scientific Research and Equipment Development Project of Chinese Academy of Sciences[YZ201457] ; Beijing Natural Science Foundation[7174314]
WOS关键词	AUTOLOGOUS BONE-MARROW ; STEROID-ASSOCIATED OSTEONECROSIS ; AVASCULAR NECROSIS ; STROMAL CELLS ; OSTEOGENIC DIFFERENTIATION ; EARLY-STAGE ; INTRAVENOUS TRANSPLANTATION ; CORE DECOMPRESSION ; MONONUCLEAR-CELLS ; RECEPTOR-GAMMA
WOS研究方向	Cell Biology
语种	英语
出版者	HINDAWI LTD
WOS记录号	WOS:000456842700001
资助机构	National Key Research Program of China ; National Natural Science Foundation of China ; Key Research Program of the Chinese Academy of Sciences ; Scientific Research and Equipment Development Project of Chinese Academy of Sciences ; Beijing Natural Science Foundation
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/25315]
专题	中国科学院自动化研究所
通讯作者	Chai, Wei; Tian, Jie
作者单位	1.Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China 2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yi,Ma, Xibo,Chai, Wei,et al. Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head[J]. STEM CELLS INTERNATIONAL,2019:13.
APA	Wang, Yi,Ma, Xibo,Chai, Wei,&Tian, Jie.(2019).Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head.STEM CELLS INTERNATIONAL,13.
MLA	Wang, Yi,et al."Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head".STEM CELLS INTERNATIONAL (2019):13.